Please use this identifier to cite or link to this item:
Título : Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
Autor : Rubinstein Guichón, Mara Roxana 
Burgueño, Adriana Laura 
Quiroga, Sofia 
Wald, Miriam Ruth 
Genaro, Ana María 
Fecha de publicación : 2023
Editorial : MDPI
Cita : Rubinstein, M.R., Burgueño, A.L., Quiroga, S., Wald, M.R., Genaro, A.M. Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure [en línea]. Cells. 2023, 12, 1735. doi: 10.3390/cells12131735. Disponible en:
Resumen : Abstract: Abstract: The term ‘perinatal environment’ refers to the period surrounding birth, which plays a crucial role in brain development. It has been suggested that dynamic communication between the neuro–immune system and gut microbiota is essential in maintaining adequate brain function. This interaction depends on the mother’s status during pregnancy and/or the newborn environment. Here, we show experimental and clinical evidence that indicates that the perinatal period is a critical window in which stress-induced immune activation and altered microbiota compositions produce lasting behavioral consequences, although a clear causative relationship has not yet been established. In addition, we discuss potential early treatments for preventing the deleterious effect of perinatal stress exposure. In this sense, early environmental enrichment exposure (including exercise) and melatonin use in the perinatal period could be valuable in improving the negative consequences of early adversities. The evidence presented in this review encourages the realization of studies investigating the beneficial role of melatonin administration and environmental enrichment exposure in mitigating cognitive alteration in offspring under perinatal stress exposure. On the other hand, direct evidence of microbiota restoration as the main mechanism behind the beneficial effects of this treatment has not been fully demonstrated and should be explored in future studies.
ISSN : 2073-4409
Disciplina: MEDICINA
DOI: 10.3390/cells12131735
Derechos: Acceso abierto
Appears in Collections:Artículos

Files in This Item:
File Description SizeFormat
current-undestangind-roles.pdf1,45 MBAdobe PDFThumbnail
Show full item record

Page view(s)

checked on Apr 27, 2024


checked on Apr 27, 2024

Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons