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https://repositorio.uca.edu.ar/handle/123456789/16987
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Vallés, Ana Sofía | es |
dc.contributor.author | Barrantes, Francisco José | es |
dc.date.accessioned | 2023-08-25T13:15:27Z | - |
dc.date.available | 2023-08-25T13:15:27Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Vallés, A. S., Barrantes, F. J. Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases [en línea]. Cells. 2023, 12(16). doi:10.3390/cells12162051. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16987 | es |
dc.identifier.issn | 2073-4409 (online) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/16987 | - |
dc.description.abstract | Abstract: The cholinergic system plays an essential role in brain development, physiology, and pathophysiology. Herein, we review how specific alterations in this system, through genetic mutations or abnormal receptor function, can lead to aberrant neural circuitry that triggers disease. The review focuses on the nicotinic acetylcholine receptor (nAChR) and its role in addiction and in neurodegenerative and neuropsychiatric diseases and epilepsy. Cholinergic dysfunction is associated with inflammatory processes mainly through the involvement of α7 nAChRs expressed in brain and in peripheral immune cells. Evidence suggests that these neuroinflammatory processes trigger and aggravate pathological states. We discuss the preclinical evidence demonstrating the therapeutic potential of nAChR ligands in Alzheimer disease, Parkinson disease, schizophrenia spectrum disorders, and in autosomal dominant sleep-related hypermotor epilepsy. PubMed and Google Scholar bibliographic databases were searched with the keywords indicated below. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Multidisciplinary Digital Publishing Institute | es |
dc.rights | Acceso abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Cells.Vol.12, No.16, 2023 | es |
dc.subject | ENFERMEDAD DE ALZHEIMER | es |
dc.subject | ENFERMEDAD DE PARKINSON | es |
dc.subject | EPILEPSIA | es |
dc.subject | ESPECTRO DE ESQUIZOFRENIA | es |
dc.subject | ADICCIONES | es |
dc.subject | SALUD | es |
dc.subject | ENFERMEDADES | es |
dc.title | Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.3390/cells12162051 | - |
uca.disciplina | MEDICINA | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Vallés, Ana Sofía. Universidad Nacional del Sur. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina | es |
uca.affiliation | Fil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina; Argentina | es |
uca.affiliation | Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina | es |
uca.version | publishedVersion | es |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Neurobiología Molecular | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-4745-681X | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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