Por favor, use este identificador para citar o enlazar este ítem: https://repositorio.uca.edu.ar/handle/123456789/1656
Título : Melatonin in mitochondrial dysfunction and related disorders
Autor : Srinivasan, Venkataramanujan 
Spence, David Warren 
Pandi Perumal, Seithikurippu R. 
Brown, Gregory M. 
Cardinali, Daniel Pedro 
Palabras clave : MELATONINARECEPTORES DE MELATONINAFUNCION MITOCONDRIALENFERMEDADES NEUROGENERATIVAS
Fecha de publicación : 2011
Editorial : Hindawi
Cita : Srinivasan, V., et al. Melatonin in mitochondrial dysfunction and related disorders [en línea]. International Journal of Alzheimer's Disease. 2011. doi:10.4061/2011/326320. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1656
Resumen : Abstract: Mitochondrial dysfunction is considered one of the major causative factors in the aging process, ischemia/reperfusion (I/R), septic shock, and neurodegenerative disorders like Parkinson’s disease (PD), Alzheimer’s disease (AD), and Huntington’s disease (HD). Increased free radical generation, enhanced mitochondrial inducible nitric oxide (NO) synthase activity, enhancedNOproduction, decreased respiratory complex activity, impaired electron transport system, and opening of mitochondrial permeability transition pore all have been suggested as factors responsible for impaired mitochondrial function. Melatonin, the major hormone of the pineal gland, also acts as an antioxidant and as a regulator of mitochondrial bioenergetic function. Both in vitro and in vivo, melatonin was effective for preventing oxidative stress/nitrosative stress-induced mitochondrial dysfunction seen in experimental models of PD, AD, and HD. In addition, melatonin is known to retard aging and to inhibit the lethal effects of septic shock or I/R lesions by maintaining respiratory complex activities, electron transport chain, and ATP production in mitochondria. Melatonin is selectively taken up by mitochondrial membranes, a function not shared by other antioxidants. Melatonin has thus emerged as a major potential therapeutic tool for treating neurodegenerative disorders such as PD or AD, and for preventing the lethal effects of septic shock or I/R.
URI : https://repositorio.uca.edu.ar/handle/123456789/1656
ISSN : 2090-8024 (Print)
2090-0252 (Online)
Disciplina: MEDICINA
DOI: 10.4061/2011/326320
Derechos: Acceso Abierto
Aparece en las colecciones: Artículos

Ficheros en este ítem:
Fichero Descripción Tamaño Formato
melatonin-mitochondrial-dysfunction-related-disorders.pdf261,26 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro Dublin Core completo del ítem

Visualizaciones de página(s)

174
comprobado en 28-mar-2024

Descarga(s)

207
comprobado en 28-mar-2024

Google ScholarTM

Consultar


Altmetric


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons