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Título : Melatonin : a pleiotropic, orchestrating regulator molecule
Autor : Srinivasan, Venkataramanujan 
Pandi Perumal, Seithikurippu R. 
Brown, Gregory M. 
Cardinali, Daniel Pedro 
Spence, David Warren 
Hardeland, Rüdiger 
Fecha de publicación : 2011
Editorial : Elsevier
Cita : Srinivasan, V., et al. Melatonin : a pleiotropic, orchestrating regulator molecule [en línea]. Preprint de artículo publicado en Progress in Neurobiology. 2011, 93. doi:10.1016/j.pneurobio.2010.12.004. Disponible en:
Resumen : Abstract: Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues and cells. It acts via G protein-coupled receptors expressed in various areas of the central nervous system and in peripheral tissues. Parallel signaling mechanisms lead to cell-specific control and recruitment of downstream factors, including various kinases, transcription factors and ion channels. Additional actions via nuclear receptors and other binding sites are likely. By virtue of high receptor density in the circadian pacemaker, melatonin is involved in the phasing of circadian rhythms and sleep promotion. Additionally, it exerts effects on peripheral oscillators, including phase coupling of parallel cellular clocks based on alternate use of core oscillator proteins. Direct central and peripheral actions concern the up- or downregulation of various proteins, among which inducible and neuronal NO synthases seem to be of particular importance for antagonizing inflammation and excitotoxicity. The methoxyindole is also synthesized in several peripheral tissues, so that the total content of tissue melatonin exceeds by far the amounts in the circulation. Emerging fields in melatonin research concern receptor polymorphism in relation to various diseases, the control of sleep, the metabolic syndrome, weight control, diabetes type 2 and insulin resistance, and mitochondrial effects. Control of electron flux, prevention of bottlenecks in the respiratory chain and electron leakage contribute to the avoidance of damage by free radicals and seem to be important in neuroprotection, inflammatory diseases and, presumably, aging. Newly discovered influences on sirtuins and downstream factors indicate that melatonin has a role in mitochondrial biogenesis.
ISSN : 0301-0082
Disciplina: MEDICINA
DOI: 10.1016/j.pneurobio.2010.12.004
Derechos: Acceso Abierto
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