Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/1649
Título : Orthostatic hypotension in Parkinson's disease
Autor : Pérez Lloret, Santiago 
Rey, Verónica 
Pavy-Le Traon, Anne 
Rascol, Olivier 
Palabras clave : HIPOTENSION ORTOSTATICAENFERMEDAD DE PARKINSONEPIDEMIOLOGIAMEDICINA BASADA EN EVIDENCIAFLUDROCORTISONA
Fecha de publicación : 2013
Editorial : Future Medicine
Cita : Pérez Lloret, S., et al. Orthostatic hypotension in Parkinson's disease [en línea]. Preprint del documento publicado en Neurodegenerative Disease Management. 2013, 3 (4). doi:10.2217/nmt.13.30. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1649
Resumen : Abstract: Orthostatic hypotension (OH) is a frequent non-motor symptom in Parkinson’s Disease (PD) affecting between 22.9 and 38.4% of patients. OH is related in PD to increased risk of falls and possibly to cognitive dysfunction and increased mortality. These data emphasizes the importance of its prompt recognition and treatment. OH is related to pre-ganglionic and post-ganglionic adrenergic denervation, but other factors such as drugs, heat, meals or alcohol intake might also induce or aggravate it. Evidence about the efficacy and safety of pharmacological or non-pharmacological strategies for OH treatment in PD is weak. Non-pharmacological measures include liberal addition of salt to the diet, exercise, compression stocking or physical maneuvers. Severe cases may be treated with midodrine or fludrocortisone. Some results suggest that droxidopa and fipamezole might be effective treatments. We finish this review article by discussing the most important unanswered questions about PD-related OH, which might be the focus of future research
URI : https://repositorio.uca.edu.ar/handle/123456789/1649
ISSN : 1758-2024 (impreso)
1758-2032 (online)
Disciplina: MEDICINA
DOI: 10.2217/nmt.13.30
Derechos: Acceso Abierto
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