Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/1627
Título : Melatonin, immune function and cancer
Autor : Srinivasan, Venkataramanujan 
Pandi Perumal, Seithikurippu R. 
Brzezinski, Amnon 
Bhatnagar, Kunwar P. 
Cardinali, Daniel Pedro 
Palabras clave : MELATONINAMELANOMAESTRES OXIDATIVONEOPLASIAS DE LA MAMANEOPLASIAS DEL COLONNEOPLASIAS DEL SISTEMA DIGESTIVOLINFOCITOS T COLABORADORESCANCER
Fecha de publicación : 2011
Editorial : Bentham Science
Cita : Srinivasan, V., et al. Melatonin, immune function and cancer [en línea]. Preprint de artículo publicado en Recent Patents on Endocrine, Metabolic & Immune Drug Discovery. 2011, 5 (2). doi:10.2174/187221411799015408. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1627
Resumen : Abstract: Melatonin is a natural substance ubiquitous in distribution and present in almost all species ranging from unicellular organisms to humans. In mammals, melatonin is synthesized not only in the pineal gland but also in many other parts of the body, including the eyes, bone marrow, gastrointestinal tract, skin and lymphocytes. Melatonin influences almost every cell and can be traced in membrane, cytoplasmic, mitochondrial and nuclear compartments of the cell. The decline in the production of melatonin with age has been suggested as one of the major contributors to immunosenescence and development of neoplastic diseases. Melatonin is a natural antioxidant with immunoenhancing properties. T‐helper cells play an important role for protection against malignancy and melatonin has been shown to enhance T‐helper cell response by releasing interleukin‐2, interleukin‐10 and interferon‐γ. Melatonin is effective in suppressing neoplastic growth in a variety of tumors like melanoma, breast cancer and ovarian and colorectal cancer. As an adjuvant therapy, melatonin can be beneficial in treating patients suffering from breast cancer, hepatocellular carcinoma or melanoma.
URI : https://repositorio.uca.edu.ar/handle/123456789/1627
ISSN : 1872-2148 (impreso)
2212-3334 (online)
Disciplina: MEDICINA
DOI: 10.2174/187221411799015408
Derechos: Acceso Abierto
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