Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/1624
Título : Pregabalin beneficial effects on sleep quality or health-related quality of life are poorly correlated with reduction on pain intensity after an eight-week treatment course
Autor : Pérez Lloret, Santiago 
Meza Rojas, Gloria 
Menoni, María Celia 
Ruiz, Gabriela 
Velásquez, Carolina 
Rodriguez, Hernán 
Rey, Verónica 
Cardinali, Daniel Pedro 
Palabras clave : PREGABALINASUEÑODOLORCALIDAD DE VIDASALUD
Fecha de publicación : 2012
Editorial : Lippincott, Williams & Wilkins
Cita : Pérez Lloret, S., et al. Pregabalin beneficial effects on sleep quality or health-related quality of life are poorly correlated with reduction on pain intensity after an eight-week treatment course [en línea]. Preprint del documento publicado en Clinical Neuropharmacology 2012, 35 (1). Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1624
Resumen : Abstract: Pregabalin (PGB) is an anticonvulsivant drug that binds to α2-δ subunit of the N-type voltagedependent Ca-channel (VDCC). VDCC-containing subunits appear to be involved in presynaptic regulation of neurotransmitter release. It has been shown that PGB is capable of inhibiting glutamate, noradrenaline, acetylcholine and substance P release at several different central nervous system locations including the neocortex, the amygdala, the hippocampus, the striatum, the spinal cord, the cerebellum and the habenula. PGB is approved by the United States Food and Drug Administration for the treatment of painful diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia, and as adjunctive therapy in adults with partial-onset seizure disorder. In Europe, pregabalin is also approved for neuropathic pain and generalized anxiety disorder. PGB effects on sleep quality and Health-related Quality of Life (HRQoL) have been studied in many clinical trials. For example, a recent meta-analysis has shown that PGB 150-600 mg/day significantly improved pain-related sleep interference in patients with neuropathic pain. HRQoL was also improved by PGB. It has been suggested that improvements on sleep or HRQoL may be correlated to PGB analgesic effects, but the magnitude of such correlation remains unknown. Therefore, we conducted the present study aiming at further exploring the correlation between changes in pain intensity, sleep quality and HRQoL after a PGB 8-week treatment course.
URI : https://repositorio.uca.edu.ar/handle/123456789/1624
ISSN : 0362-5664
1537-162X (online)
Disciplina: MEDICINA
DOI: 10.1097/WNF.0b013e31823df2dc
Derechos: Acceso Abierto
Appears in Collections:Artículos

Files in This Item:
File Description SizeFormat
pregabalin-beneficial-effects-sleep-quality.pdf231,05 kBAdobe PDFThumbnail
View/Open
Show full item record

Page view(s)

158
checked on Mar 8, 2021

Download(s)

54
checked on Mar 8, 2021

Google ScholarTM

Check


Altmetric


This item is licensed under a Creative Commons License Creative Commons