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Título : Measurement of melatonin in body fluids : standards, protocols, and procedures
Autor : Alves de Almeida, Eduardo 
Di Mascio, Paolo 
Harumi, Tatsuo 
Moscovitch, Adam 
Hardeland, Rüdiger 
Cardinali, Daniel Pedro 
Brown, Gregory M. 
Pandi Perumal, Seithikurippu R. 
Fecha de publicación : 2011
Editorial : Springer
Cita : Alves de Almeida, E., et al. Measurement of melatonin in body fluids : standards, protocols, and procedures [en línea]. Child's nervous system. 2011, 27 (6). doi:10.1007/s00381-010-1278-8. Disponible en:
Resumen : Abstract: The circadian rhythm of melatonin in saliva or plasma, or of the melatonin metabolite 6‐ sulphatoxymelatonin in urine, is a defining feature of suprachiasmatic nucleus function, the endogenous oscillatory pacemaker. These measurements are useful to evaluate problems related to the onset or offset of sleep and for assessing phase delays or advances of rhythms in entrained individuals. Additionally, they have become an important tool for psychiatric diagnosis, its use being recommended for phase typing in patients suffering from sleep and mood disorders. Thus, the development of sensitive and selective methods for the precise detection of melatonin in tissues and fluids of animals emerges as necessary. Due to its low concentration and the co‐existence of many other endogenous compounds in blood, the determination of melatonin has been an analytical challenge. This review discusses current methodologies employed for detection and quantification of melatonin in biological fluids and tissues.
ISSN : 0256-7040 (impreso)
1433-0350 (online)
Disciplina: MEDICINA
DOI: 10.1007/s00381-010-1278-8
Derechos: Acceso Abierto
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