Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/15356
Título : Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder
Autor : Wainsztein, Agustina E. 
Castro, Mariana N. 
Goldberg, Ximena 
Camacho-Téllez, Vicente 
Vulcano, Mercedes 
Abulafia, Carolina Andrea 
Ladrón de Guevara, María Soledad 
Cardoner, Narcís 
Nemeroff, Charles B. 
Menchón, José M. 
Soriano-Mas, Carles 
Villarreal, Mirta F. 
Guinjoan, Salvador M. 
Palabras clave : REGULACION EMOCIONALDEPRESIONRESONANCIA MAGNETICA NUCLEARBORDERLINESISTEMA NERVIOSO AUTONOMOADVERSIDAD VIDA TEMPRANATRASTORNO PSICOLOGICO
Fecha de publicación : 2021
Editorial : Elsevier
Cita : Wainsztein, A. E. et al. Childhood adversity modulation of central autonomic network components during cognitive regulation of emotion in major depressive disorder and borderline personality disorder [en línea]. Psychiatry Research Neuroimaging. 2021, 318, 111394. doi: 10.1016/j.pscychresns.2021.111394. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/15356
Resumen : Abstract: Adverse childhood experiences (ACEs) have lifelong effects on emotional behavior and are frequent in Borderline Personality Disorder (BPD) and Major Depressive Disorder (MDD). The Central Autonomic Network (CAN), which modulates heart rate variability (HRV), comprises brain regions that mediate emotion regulation processes. However, it remains unclear the effect of ACEs on CAN dynamics and its relationship with HRV in these disorders. We studied the effects of ACEs on the brain and HRV simultaneously, during regulation of psychological stress in 19 BPD, 20 MDD and 20 healthy controls (HC). Participants underwent a cognitive reappraisal task during fMRI with simultaneous ECG acquisition. ACEs exposure was associated with increased activity of CAN and salience network components in patients with MDD compared to BPD during cognitive reappraisal. A brain-autonomic coupling was found in BPD relative to HC during emotion regulation, whereby greater activity of left anterior cingulate and medial superior frontal gyrus areas was coupled with increased HRV. Results suggest that ACEs exposure is associated with a distinct activation of the CAN and salience network regions governing responses to psychological stress in MDD compared to BPD. These alterations may constitute a distinctive neurobiological mechanism for abnormal emotion processing and regulation related to ACEs in MDD.
URI : https://repositorio.uca.edu.ar/handle/123456789/15356
ISSN : 0925-4927
Disciplina: MEDICINA
DOI: 10.1016/j.pscychresns.2021.111394
Derechos: Acceso restringido
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