Por favor, use este identificador para citar o enlazar este ítem:
https://repositorio.uca.edu.ar/handle/123456789/15003
Título : | The synaptic lipidome in health and disease | Autor : | Vallés, Ana Sofía Barrantes, Francisco José |
Palabras clave : | SINAPSIS; ESPINA DENDRÍTICA; MEMBRANA DE PLASMA; METABOLISMO DE LÍPIDOS; METABOLISMO CEREBRAL; HOMEOSTASIS CEREBRAL; SINAPTOPATÍAS | Fecha de publicación : | 2022 | Editorial : | Elsevier | Cita : | Vallés, A. S., Barrantes, F. J. The synaptic lipidome in health and disease [en línea]. Postprint de artículo publicado en Biochimica et Biophysica Acta (BBA) - Biomembranas. 2022, 1864 (11), 184033. doi: 10.1016/j.bbamem.2022.184033. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/15003 | Resumen : | Abstract: Adequate homeostasis of lipid, protein and carbohydrate metabolism is essential for cells to perform highly specific tasks in our organism, and the brain, with its uniquely high energetic requirements, posesses singular characteristics. Some of these are related to its extraordinary dotation of synapses, the specialized subcelluar structures where signal transmission between neurons occurs in the central nervous system. The post-synaptic compartment of excitatory synapses, the dendritic spine, harbors key molecules involved in neurotransmission tightly packed within a minute volume of a few femtoliters. The spine is further compartmentalized into nanodomains that facilitate the execution of temporo-spatially separate functions in the synapse. Lipids play important roles in this structural and functional compartmentalization and in mechanisms that impact on synaptic transmission. This review analyzes the structural and dynamic processes involving lipids at the synapse, highlighting the importance of their homeostatic balance for the physiology of this complex and highly specialized structure, and underscoring the pathologies associated with disbalances of lipid metabolism, particularly in the perinatal and late adulthood periods of life. Although small variations of the lipid profile in the brain take place throughout the adult lifespan, the pathophysiological consequences are clinically manifested mostly during late adulthood. Disturbances in lipid homeostasis in the perinatal period leads to alterations during nervous system development, while in late adulthood they favor the occurrence of neurodegenerative diseases. | URI : | https://repositorio.uca.edu.ar/handle/123456789/15003 | ISSN : | 0005-2736 (online) 0006-3002 |
Disciplina: | MEDICINA | DOI: | 10.1016/j.bbamem.2022.184033 | Derechos: | Acceso abierto |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
synaptic-lipidome-health.pdf | 1,27 MB | Adobe PDF | Visualizar/Abrir |
Visualizaciones de página(s)
91
comprobado en 27-abr-2024
Descarga(s)
46
comprobado en 27-abr-2024
Google ScholarTM
Consultar
Altmetric
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons