Por favor, use este identificador para citar o enlazar este ítem: https://repositorio.uca.edu.ar/handle/123456789/14725
Título : Nicotine modulates mitochondrial dynamics in hippocampal neurons
Autor : Godoy, Juan A. 
Valdivieso, Ángel Gabriel 
Inestrosa, Nibaldo C. 
Palabras clave : MITOCONDRIASNICOTINANEURONASHIPOCAMPO
Fecha de publicación : 2018
Editorial : Springer
Cita : Godoy, J.A., Valdivieso, A.G., Inestrosa, N.C. Nicotine modulates mitochondrial dynamics in hippocampal neurons [en línea]. Molecular Neurobiology. 2018, 55 doi:10.1007/s12035-018-1034-8 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14725
Resumen : Abstract: Mitochondria are widely recognized as fundamental organelles for cellular physiology and constitute the main energy source for different cellular processes. The location, morphology, and interactions of mitochondria with other organelles, such as the endoplasmic reticulum (ER), have emerged as critical events capable of determining cellular fate. Mitochondria-related functions have proven particularly relevant in neurons; mitochondria are necessary for proper neuronal morphogenesis and the highly energy-demanding synaptic transmission process. Mitochondrial health depends on balanced fusion-fission events, termed mitochondrial dynamics, to repair damaged organelles and/or improve the quality of mitochondrial function, ATP production, calcium homeostasis, and apoptosis, which represent some mitochondrial functions closely related to mitochondrial dynamics. Several neurodegenerative disorders, such as Alzheimer's, Parkinson's, and Huntington's diseases, have been correlated with severe mitochondrial dysfunction. In this regard, nicotine, which has been associated with relevant neuroprotective effects mainly through activation of the nicotinic acetylcholine receptor (nAChR), exerts its effects at least in part by acting directly on mitochondrial physiology and morphology. Additionally, a recent description of mitochondrial nAChR localization suggests a nicotine-dependent mitochondrial function. In the present work, we evaluated in cultured hipocampal neurons the effects of nicotine on mitochondrial dynamics by assessing mitochondrial morphology, membrane potential, as well as interactions between mitochondria, cytoskeleton and IP3R, levels of the cofactor PGC-1α, and fission-fusion-related proteins. Our results suggest that nicotine modulates mitochondrial dynamics and influences mitochondrial association from microtubules, increasing IP3 receptor clustering showing modulation between mitochondria-ER communications, together with the increase of mitochondrial biogenesis.
URI : https://repositorio.uca.edu.ar/handle/123456789/14725
ISSN : 0893-7648
1559-1182 (online)
Disciplina: MEDICINA
DOI: 10.1007/s12035-018-1034-8
Derechos: info:eu-repo/semantics/closedAccess
Aparece en las colecciones: Artículos

Ficheros en este ítem:
Fichero Descripción Tamaño Formato Usuarios registrados haga click en: Login
nicotine-modulates-mitochondrial.pdf5,01 MBAdobe PDF  
thumb.png140,76 kBimage/pngVista previa
Visualizar/Abrir
Mostrar el registro Dublin Core completo del ítem

Visualizaciones de página(s)

56
comprobado en 28-mar-2024

Descarga(s)

13
comprobado en 28-mar-2024

Google ScholarTM

Consultar


Altmetric


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons