Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/14598
Título : Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress
Autor : Pascuan, C.G. 
Di Rosso, M.E. 
Pivoz-Avedikian, J.E. 
Wald, M.R. 
Zorrilla Zubilete, M.A. 
Genaro, A.M. 
Palabras clave : ESTRES PRENATALMEMORIA ESPACIALNEUROTROFINASCORTICOSTERONATRASTORNOS DE LA MEMORIAEMBARAZO
Fecha de publicación : 2017
Editorial : Elsevier
Cita : Pascuan, C.G. et al. Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress [en línea]. Physiology & Behavior. 2017, 173. doi: 10.1016/j.physbeh.2017.01.045. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14598
Resumen : Abstract:ESTRÉS PRENATAL Much evidence has suggested that early life adversity can have a lasting effect on behavior. The aim of this study was to explore the impact of prenatal exposure to stress on cognition in adult life and how it impacts chronic stress situations. In addition, we investigated the participation of glucocorticoids, neurotrophins and cytokines in prenatal stress effects. For this purpose, pregnant mice were placed in a cylindrical restraint tube for 2 h daily during the last week of pregnancy. Control pregnant females were left undisturbed during their entire pregnancy period. Object-in-place task results showed that adult female mice exposed to prenatal stress exhibited an impairment in spatial memory. However, in the alternation test this memory deficit was only found in prenatally stressed mice submitted to chronic stress. This alteration occurred in parallel with a decrease in BDNF, an increase in glucocorticoid receptors and an alteration of Th1/Th2 in the hippocampus. Interestingly, these changes were observed in peripheral lymph nodes as well. However, none of the mentioned changes were observed in adult male mice. These results indicate that lymphoid cells could be good candidates as peripheral markers of susceptibility to behavioral alterations associated with prenatal exposure to stress.
URI : https://repositorio.uca.edu.ar/handle/123456789/14598
ISSN : 0031-9384
1873-507X (online)
Disciplina: MEDICINA
DOI: 10.1016/j.physbeh.2017.01.045
Derechos: Acceso restringido
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