Por favor, use este identificador para citar o enlazar este ítem:
https://repositorio.uca.edu.ar/handle/123456789/1457
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Furmento, Verónica A. | es |
dc.contributor.author | Marino, Julieta | es |
dc.contributor.author | Blank, Viviana C. | es |
dc.contributor.author | Cayrol, María Florencia | es |
dc.contributor.author | Cremaschi, Graciela A. | es |
dc.contributor.author | Aguilar, Rubén C. | es |
dc.contributor.author | Roguin, Leonor P. | es |
dc.date.accessioned | 2019-05-02T13:56:19Z | - |
dc.date.available | 2019-05-02T13:56:19Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Furmento, V. A., et al. Granulocyte colony-stimulating factor (G-CSF) upregulates β1 integrin and increases migration of human trophoblast Swan 71 cells via PI3K and MAPK activation [en línea]. Postprint del documento publicado en Experimental Cell Research. 2016, 342 (2). doi:10.1016/j.yexcr.2016.03.005. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1457 | es |
dc.identifier.issn | 0014-4827 | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/1457 | - |
dc.description.abstract | Abstract: Multiple cytokines and growth factors expressed at the fetal-maternal interface are involved in the regulation of trophoblast functions and placental growth, but the role of G-CSF has not been completely established. Based on our previous study showing that G-CSF increases the activity of matrix metalloproteinase-2 and the release of vascular endothelial growth factor in Swan 71 human trophoblast cells, in this work we explore the possible contribution of G-CSF to cell migration and the G-CSF-triggered signaling pathway. We found that G-CSF induced morphological changes on actin cytoskeleton consistent with a migratory cell phenotype. G-CSF also up-regulated the expression levels of β1 integrin and promoted Swan 71 cell migration. By using selective pharmacological inhibitors and dominant negative mutants we showed that PI3K, Erk 1/2 and p38 pathways are required for promoting Swan 71 cell motility. It was also demonstrated that PI3K behaved as an upstream regulator of Erk 1/2 and p38 MAPK. In addition, the increase of β1 integrin expression was dependent on PI3K activation. In conclusion, our results indicate that G-CSF stimulates β1 integrin expression and Swan 71 cell migration by activating PI3K and MAPK signaling pathways, suggesting that G-CSF should be considered as an additional regulatory factor that contributes to a successful embryo implantation and to the placenta development. | es |
dc.format | application/pdf | es |
dc.language | eng | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.rights | Acceso Abierto | es |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | es |
dc.source | Experimental Cell Research; 2016 Mar 15;342(2):125-34 | es |
dc.subject | EMBRION HUMANO | es |
dc.subject | BIOLOGIA | es |
dc.subject | QUIMICA BIOLOGICA | es |
dc.subject | PLACENTA | es |
dc.title | Granulocyte colony-stimulating factor (G-CSF) upregulates β1 integrin and increases migration of human trophoblast Swan 71 cells via PI3K and MAPK activation | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1016/j.yexcr.2016.03.005 | - |
uca.path | Facultad de Ciencias Médicas|Instituto de Investigaciones Biomédicas (BIOMED UCA-CONICET) | es |
uca.disciplina | MEDICINA | es |
uca.filename | /home/data-uca-generic/folder_generic/IIBiomedicas/granulocyte-colony-stimulating/metadata.xml | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Furmento, Verónica A. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas; Argentina | es |
uca.affiliation | Fil: Marino, Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas; Argentina | es |
uca.affiliation | Fil: Blank, Viviana C. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas; Argentina | es |
uca.affiliation | Fil: Cayrol, María Florencia. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Cremaschi, Graciela A. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Aguilar, Ruben Claudio. Department of Biological Sciences. Purdue University; Estados Unidos | es |
uca.affiliation | Fil: Roguin, Leonor P. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas; Argentina | es |
uca.version | acceptedVersion | es |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Neuroinmunomodulación y Oncología Molecular | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Neuroinmunomodulación y Oncología Molecular | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-1131-1723 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
granulocyte-colony-stimulating | 3 MB | Adobe PDF | Visualizar/Abrir |
Visualizaciones de página(s)
160
comprobado en 27-abr-2024
Descarga(s)
189
comprobado en 27-abr-2024
Google ScholarTM
Consultar
Altmetric
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons