The chloride anion acts as a second messenger in mammalian cells modifying the expression of specific genes

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Título :	The chloride anion acts as a second messenger in mammalian cells modifying the expression of specific genes
Autor :	Valdivieso, Ángel Gabriel Clauzure, Mariángeles Massip Copiz, María Macarena Santa Coloma, Tomás Antonio
Palabras clave :	GENETICA; BIOLOGIA CELULAR; CLORURO INTRACELULAR; FIBROSIS QUISTICA; BIOMEDICINA; SEGUNDO MENSAJERO; BIOLOGIA MOLECULAR; GENES CFTR DEPENDIENTES
Fecha de publicación :	2016
Editorial :	Karger International
Cita :	Valdivieso, A. G. et al. The chloride anion acts as a second messenger in mammalian cells modifying the espression of specific genes [en línea]. Cellular physiology and biochemistry. 2016, 38. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1454
Resumen :	Abstract: Background/Aims: Cystic Fibrosis (CF) is caused by mutations in the CFTR gene, encoding a cAMP-activated chloride (Cl-) channel. We have previously demonstrated that the expression of several genes can be modulated by the CFTR activity; among them, SRC, MTND4, CISD1, and IL1B. However, the CFTR signalling mechanism involved in the expression of CFTRdependent genes is unknown. The aim of this work was to determine if intracellular chloride (Cl-Clconcentration, regulating in turn the expression of specific genes
URI :	https://repositorio.uca.edu.ar/handle/123456789/1454
ISSN :	1421-9778
Disciplina:	MEDICINA
Derechos:	Acceso Abierto
Aparece en las colecciones:	Artículos