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Título : The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies
Autor : Sterle, Helena Andrea 
Barreiro Arcos, María Laura 
Valli, Eduardo 
Paulazo, Maria Alejandra 
Méndez Huergo, Santiago Patricio 
Blidner, Ada Gabriela 
Cayrol, María Florencia 
Díaz Flaqué, María Celeste 
Klecha, Alicia Juana 
Medina, Vanina Araceli 
Colombo, Lucas Luis 
Rabinovich, Gabriel Adrián 
Cremaschi, Graciela A. 
Fecha de publicación : 2016
Editorial : Springer
Cita : Sterle, H. A, et al. The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies [en línea]. Postprint del documento publicado en Jourrnal of Molecular Medicine. 2016, 94 (4). doi:10.1007/s00109-015-1363-2. Disponible en:
Resumen : Abstract: In spite of considerable evidence on the regulation of immunity by thyroid hormones, the impact of the thyroid status in tumor immunity is poorly understood. Here, we evaluated the antitumor immune responses evoked in mice with different thyroid status (euthyroid, hyperthyroid, and hypothyroid) that developed solid tumors or metastases after inoculation of syngeneic T lymphoma cells. Hyperthyroid mice showed increased tumor growth along with increased expression of cell cycle regulators compared to hypothyroid and control tumor-bearing mice. However, hypothyroid mice showed a higher frequency of metastases than the other groups. Hyperthyroid mice bearing tumors displayed a lower number of tumor-infiltrating T lymphocytes, lower percentage of functional IFN-γ-producing CD8+ T cells, and higher percentage of CD19+ B cells than euthyroid tumor-bearing mice. However, no differences were found in the distribution of lymphocyte subpopulations in tumor-draining lymph nodes (TDLNs) or spleens among different experimental groups. Interestingly, hypothyroid TDLN showed an increased percentage of regulatory T (Treg) cells, while hyperthyroid mice displayed increased number and activity of splenic NK cells, which frequency declined in spleens from hypothyroid mice. Moreover, a decreased number of splenic myeloid-derived suppressor cells (MDSCs) were found in tumor-bearing hyperthyroid mice as compared to hypothyroid or euthyroid mice. Additionally, hyperthyroid mice showed increased cytotoxic activity, which declined in hypothyroid mice. Thus, low levels of intratumoral cytotoxic activity would favor tumor local growth in hyperthyroid mice, while regional and systemic antitumor response may contribute to tumor dissemination in hypothyroid animals. Our results highlight the importance of monitoring the thyroid status in patients with T cell lymphomas.
ISSN : 0946-2716
Disciplina: MEDICINA
DOI: 10.1007/s00109-015-1363-2
Derechos: Acceso Abierto. 1 año de embargo
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