Por favor, use este identificador para citar o enlazar este ítem: https://repositorio.uca.edu.ar/handle/123456789/14438
Título : Dendritic spine membrane proteome and its alterations in autistic spectrum disorder
Autor : Vallés, Ana Sofía 
Barrantes, Francisco José 
Palabras clave : AUTISMORECEPTOR DE ACETILCOLINASINAPTOPATIAESPINA DENDRITICASINDROME X FRAGILTRASTORNOS DEL ESPECTRO AUTISTA
Fecha de publicación : 2022
Editorial : Academic Press
Cita : Vallés, A.S., Barrantes, F.J. Dendritic spine membrane proteome and its alterations in autistic spectrum disorder [en línea]. En: Donev, R. (ed.). Advances in Protein Chemistry and Structural Biology: Volume 128 Membrane Proteins. Londres: Academic Press, 2022 doi:10.1016/bs.apcsb.2021.09.003 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14438
Resumen : Abstract: Dendritic spines are small protrusions stemming from the dendritic shaft that constitute the primary specialization for receiving and processing excitatory neurotransmission in brain synapses. The disruption of dendritic spine function in several neurological and neuropsychiatric diseases leads to severe information-processing deficits with impairments in neuronal connectivity and plasticity. Spine dysregulation is usually accompanied by morphological alterations to spine shape, size and/or number that may occur at early pathophysiological stages and not necessarily be reflected in clinical manifestations. Autism spectrum disorder (ASD) is one such group of diseases involving changes in neuronal connectivity and abnormal morphology of dendritic spines on postsynaptic neurons. These alterations at the subcellular level correlate with molecular changes in the spine proteome, with alterations in the copy number, topography, or in severe cases in the phenotype of the molecular components, predominantly of those proteins involved in spine recognition and adhesion, reflected in abnormally short lifetimes of the synapse and compensatory increases in synaptic connections. Since cholinergic neurotransmission participates in the regulation of cognitive function (attention, memory, learning processes, cognitive flexibility, social interactions) brain acetylcholine receptors are likely to play an important role in the dysfunctional synapses in ASD, either directly or indirectly via the modulatory functions exerted on other neurotransmitter receptor proteins and spine-resident proteins.
URI : https://repositorio.uca.edu.ar/handle/123456789/14438
ISBN : 978-0-323-98895-7
ISSN : 1876-1623
Disciplina: MEDICINA
DOI: 10.1016/bs.apcsb.2021.09.003
Derechos: info:eu-repo/semantics/closedAccess
Aparece en las colecciones: Libros o partes de libro

Ficheros en este ítem:
Fichero Descripción Tamaño Formato
thumb.gif6,97 kBGIFVista previa
Visualizar/Abrir
dendritic-spine-embrane.pdf10,92 MBAdobe PDFVista previa
  
Mostrar el registro Dublin Core completo del ítem

Visualizaciones de página(s)

82
comprobado en 28-mar-2024

Descarga(s)

112
comprobado en 28-mar-2024

Google ScholarTM

Consultar


Altmetric


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons