Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/1442
Título : Melatonin and brain inflammaging
Autor : Hardeland, Rüdiger 
Cardinali, Daniel Pedro 
Brown, Gregory M. 
Pandi Perumal, Seithikurippu R. 
Palabras clave : MEDICINAMELATONINACEREBROINFLAMACIONMITOCONDRIAENFERMEDAD DE ALZHEIMERENVEJECIMIENTO
Fecha de publicación : 2015
Editorial : Elsevier
Cita : Hardeland, R., et al. Melatonin and brain inflammaging [en línea]. Postprint del documento publicado en Progress in Neurobiology. 2015, 127-128. doi:10.1016/j.pneurobio.2015.02.001. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1442
Resumen : Abstract: Melatonin is known to possess several properties of value for healthy aging, as a direct and indirect antioxidant, protectant and modulator of mitochondrial function, antiexcitotoxic agent, enhancer of circadian amplitudes, immune modulator and neuroprotectant. It is levels tend to decrease in the course of senescence and are more strongly reduced in several neurodegenerative disorders, especially Alzheimer’s disease, and in diseases related to insulin resistance such as diabetes type 2. Although the role of melatonin in aging and age-related diseases has been repeatedly discussed, the newly emerged concept of inflammaging, that is, the contribution of low-grade inflammation to senescence progression has not yet been the focus of melatonin research. This review addresses the multiple protective actions of melatonin and its kynuramine metabolites that are relevant to the attenuation of inflammatory responses and progression of inflammaging in the brain, i.e. avoidance of excitotoxicity, reduction of free radical formation by support of mitochondrial electron flux, prevention of NADPH oxidase activation and suppression of inducible nitric oxide synthase, as well as downregulation of proinflammatory cytokines. The experimental evidence is primarily discussed on the basis of aging and senescence-accelerated animals, actions in the immune system, and the relationship between melatonin and sirtuins, having properties of aging suppressors. Sirtuins act either as accessory components or downstream factors of circadian oscillators, which are also under control by melatonin. Inflammaging is assumed to strongly contribute to neurodegeneration of the circadian master clock observed in advanced senescence and, even more, in Alzheimer’s disease, a change that affects countless physiological functions.
URI : https://repositorio.uca.edu.ar/handle/123456789/1442
ISSN : 0301-0082
Disciplina: MEDICINA
DOI: 10.1016/j.pneurobio.2015.02.001
Derechos: Acceso abierto. 1 año de embargo
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