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Título : | Mitochondrial alterations and oxidative stress in cystic fibrosis | Autor : | Valdivieso, Ángel Gabriel | Palabras clave : | FIBROSIS QUISTICA; ESTRES OXIDATIVO; CFRT; INMUNIDAD | Fecha de publicación : | 2019 | Editorial : | Springer Nature | Cita : | Valdivieso, A.G. Mitochondrial alterations and oxidative stress in cystic fibrosis [en línea]. En: Chakraborti, S., Chakraborti, T., Das, S., Chattopadhyay, D. (eds.). Oxidative Stress in Lung Diseases. Springer, Singapore: 2019 doi:10.1007/978-981-13-8413-4_18 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14243 | Resumen : | Abstract: Cystic fibrosis (CF) is the most frequent autosomal recessive disease and is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Since the discovery of the deletion in the phenylalanine 508 site (ΔF508) of the CFTR gene, the study of its function as chloride channel occupied most investigations. Now, we know that CFTR is also involved in the GSH and HCO3 − transport, and its function could regulate the mitochondrial function and ROS production. In this way, the notion of the CFTR as a simple chloride channel has begun to change toward a more complex function as molecular hub that integrates different cellular signals. There is a growing body of evidence that shows mitochondrial dysfunctions and increased oxidative stress in CF. Here, we review the mitochondrial defects induced by the altered function of the CFTR in CF, focusing on oxidative stress and inflammation as targets for therapy. | URI : | https://repositorio.uca.edu.ar/handle/123456789/14243 | ISBN : | 978-981-13-8413-4 | Disciplina: | MEDICINA | DOI: | 10.1007/978-981-13-8413-4_18 | Derechos: | info:eu-repo/semantics/closedAccess |
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