Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/14229
Título : Antitumor efficacy and cardiotoxic effect of doxorubicin-loaded mixed micelles in 4T1 murine breast cancer model. Comparative studies using Doxil® and free doxorubicin
Autor : Cagel, Maximiliano 
Moretton, Marcela A. 
Bernabeu, Ezequiel 
Zubillaga, Marcelo 
Lagomarsino, Eduardo 
Vanzulli, Silvia 
Nicoud, Melisa Beatriz 
Medina, Vanina A. 
Salgueiro, María J. 
Chiappetta, Diego A. 
Palabras clave : CANCER DE MAMATRATAMIENTO FARMACOLOGICOMICELASDOXORRUBICINA
Fecha de publicación : 2020
Editorial : Elsevier
Cita : Cagel, M. et al. Antitumor efficacy and cardiotoxic effect of doxorubicin-loaded mixed micelles in 4T1 murine breast cancer model. Comparative studies using Doxil® and free doxorubicin [en línea]. Journal of Drug Delivery Science and Technology. 2020, 56(A) doi:10.1016/j.jddst.2020.101506 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14229
Resumen : Abstract: Doxorubicin-loaded mixed micelles (DOX-micelles) were formulated employing TPGS and a poloxamine (Tetronic® T1107) in order to investigate their pharmaceutical application as an alternative anticancer nanotherapy. DOX-micelles presented unimodal behaviour, exhibiting average size values of 10.7 ± 0.2 nm and 10.4 ± 0.1 nm, before and after lyophilization, respectively. The in vitro cytotoxic effect of DOX-micelles was significantly higher (p < 0.05) than Doxil® on 4T1 murine breast cancer cells. The in vitro cell-based internalization assays showed a significant augment (p < 0.05) of the intracellular DOX content for the DOX-micelles in comparison to the liposomes and free DOX in these 4T1 cells at 2 and 6 h. Besides, DOX-micelles presented higher in vivo anticancer effect than Doxil® and equivalent potency to the free drug. Moreover, the in vivo histopathological toxicity studies revealed that the DOX-micelles produced significant less cardiac damage than free DOX, while the in vivo immunohistochemical assays exhibited a significantly higher DNA damage in the cardiac tissue with the free DOX than with our DOX-micelles. All these results demonstrate that our novel nanotechnological platform could successfully deliver DOX to the tumor with reduced cardiotoxicity, thus showing promising clinical potential as an anticancer drug delivery carrier.
URI : https://repositorio.uca.edu.ar/handle/123456789/14229
ISSN : 1773-2247
Disciplina: MEDICINA
DOI: 10.1016/j.jddst.2020.101506
Derechos: Acceso abierto
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