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Título : | Antitumor efficacy and cardiotoxic effect of doxorubicin-loaded mixed micelles in 4T1 murine breast cancer model. Comparative studies using Doxil® and free doxorubicin | Autor : | Cagel, Maximiliano Moretton, Marcela A. Bernabeu, Ezequiel Zubillaga, Marcelo Lagomarsino, Eduardo Vanzulli, Silvia Nicoud, Melisa Beatriz Medina, Vanina Araceli Salgueiro, María J. Chiappetta, Diego A. |
Palabras clave : | CANCER DE MAMA; TRATAMIENTO FARMACOLOGICO; MICELAS; DOXORRUBICINA | Fecha de publicación : | 2020 | Editorial : | Elsevier | Cita : | Cagel, M. et al. Antitumor efficacy and cardiotoxic effect of doxorubicin-loaded mixed micelles in 4T1 murine breast cancer model. Comparative studies using Doxil® and free doxorubicin [en línea]. Journal of Drug Delivery Science and Technology. 2020, 56(A) doi:10.1016/j.jddst.2020.101506 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14229 | Resumen : | Abstract: Doxorubicin-loaded mixed micelles (DOX-micelles) were formulated employing TPGS and a poloxamine (Tetronic® T1107) in order to investigate their pharmaceutical application as an alternative anticancer nanotherapy. DOX-micelles presented unimodal behaviour, exhibiting average size values of 10.7 ± 0.2 nm and 10.4 ± 0.1 nm, before and after lyophilization, respectively. The in vitro cytotoxic effect of DOX-micelles was significantly higher (p < 0.05) than Doxil® on 4T1 murine breast cancer cells. The in vitro cell-based internalization assays showed a significant augment (p < 0.05) of the intracellular DOX content for the DOX-micelles in comparison to the liposomes and free DOX in these 4T1 cells at 2 and 6 h. Besides, DOX-micelles presented higher in vivo anticancer effect than Doxil® and equivalent potency to the free drug. Moreover, the in vivo histopathological toxicity studies revealed that the DOX-micelles produced significant less cardiac damage than free DOX, while the in vivo immunohistochemical assays exhibited a significantly higher DNA damage in the cardiac tissue with the free DOX than with our DOX-micelles. All these results demonstrate that our novel nanotechnological platform could successfully deliver DOX to the tumor with reduced cardiotoxicity, thus showing promising clinical potential as an anticancer drug delivery carrier. | URI : | https://repositorio.uca.edu.ar/handle/123456789/14229 | ISSN : | 1773-2247 | Disciplina: | MEDICINA | DOI: | 10.1016/j.jddst.2020.101506 | Derechos: | info:eu-repo/semantics/closedAccess |
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