Please use this identifier to cite or link to this item:
Título : Thyroid status regulates the tumor microenvironment delineating breast cancer fate
Autor : Sterle, Helena Andrea 
Hildebrandt, Ximena 
Valenzuela Álvarez, Matías 
Paulazo, Maria Alejandra 
Gutierrez, Luciana Mariel 
Klecha, Alicia Juana 
Cayrol, María Florencia 
Díaz Flaqué, María Celeste 
Rosemblit, Cinthia 
Barreiro Arcos, María Laura 
Colombo, Lucas Luis 
Bolontrade, Marcela Fabiana 
Medina, Vanina Araceli 
Cremaschi, Graciela A. 
Fecha de publicación : 2021
Editorial : Society for Endocrinology
Cita : Sterle, H. A. et al. Thyroid status regulates the tumor microenvironment delineating breast cancer fate [en línea]. Postprint de artículo publicado en Endocrine-related cancer. 2021, 28 (7). doi: 10.1530/ERC-20-0277. Disponible en:
Resumen : Abstract: The patient’s hormonal context plays a crucial role in the outcome of cancer. However, the association between thyroid disease and breast cancer risk remains unclear. We evaluated the effect of thyroid status on breast cancer growth and dissemination in an immunocompetent mouse model. For this, hyperthyroid and hypothyroid Balb/c mice were orthotopically inoculated with triple-negative breast cancer 4T1 cells. Tumors from hyperthyroid mice showed an increased growth rate and an immunosuppressive tumor microenvironment, characterized by increased IL-10 levels and decreased percentage of activated cytotoxic T cells. On the other hand, delayed tumor growth in hypothyroid animals was associated with increased tumor infiltration of activated CD8+ cells and a high IFNγ/IL-10 ratio. Paradoxically, hypothyroid mice developed a higher number of lung metastasis than hyperthyroid animals. This was related to an increased secretion of tumor CCL2 and an immunosuppressive systemic environment, with increased proportion of regulatory T cells and IL-10 levels in spleens. A lower number of lung metastasis in hyperthyroid mice was related to the reduced presence of mesenchymal stem cells in tumors and metastatic sites. These animals also exhibited decreased percentages of regulatory T lymphocytes and myeloid-derived suppressor cells in spleens but increased activated CD8+ cells and the IFNγ/IL-10 ratio. Therefore, thyroid hormones modulate the cellular and cytokine content of the breast tumor microenvironment. A better understanding of the mechanisms involved in these effects could be a starting point for the discovery of new therapeutic targets for breast cancer.
ISSN : 1351-0088
1479-6821 (online)
Disciplina: MEDICINA
DOI: 10.1530/ERC-20-0277
Derechos: Acceso abierto
Appears in Collections:Artículos

Files in This Item:
File Description SizeFormat
thyroid-status-regulates-tumor.pdf1,06 MBAdobe PDFThumbnail
Show full item record

Page view(s)

checked on Sep 26, 2023


checked on Sep 26, 2023

Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons