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Título : Classical and non-classical thyroid hormone intracellular pathways involved in T lymphoma growth
Autor : Barreiro Arcos, María Laura 
Sterle, Helena Andrea 
Cayrol, María Florencia 
Díaz Flaqué, María Celeste 
Valli, Eduardo 
Paulazo, Maria Alejandra 
Klecha, Alicia Juana 
Cremaschi, Graciela A. 
Fecha de publicación : 2014
Editorial : Bentham Science Publishers
Cita : Barreiro Arcos, M.L. Classical and non-classical thyroid hormone intracellular pathways involved in T lymphoma growth [en línea]. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry. 2014, 14 doi:10.2174/187152221501150710125255 Disponible en:
Resumen : Abstract: Thyroid hormones (THs) are important regulators of cell physiology. They are essential for the normal development and growth of mammals, especially for the neural differentiation and the regulation of the metabolism and the immune system. THs also induce the proliferation of several cell types. In human and murine T cell lymphomas (TCL) this effect involves the participation of genomic and nongenomic mechanisms as it was described by the use of free THs and non-cell permeable THs coupled to agarose (TH-ag). The classic actions of thyroid hormones involve the alteration of gene transcription via specific nuclear receptors. The discovery of other effects, independent of this classic mechanism, characterizes a new and non-classic mechanism that involves different signaling pathways. Both, free THs and TH-ag, activate protein kinase C, extracellular signal-regulated kinases and NF-kB and they increase the intracellular calcium levels. However, only the preincubation of T cells with free THs leads to an increased intracellular content of signaling enzymes. T lymphomas display high expression levels of both, the TH nuclear receptors (TRs) and the putative membrane receptor for THs, the integrin V3, which has been demonstrated to be responsible for THs non-genomic actions. Here, we reviewed the mechanisms involved in THs modulation of the lymphocyte physiology, analyzing the interplay between genomic and nongenomic actions in T cells and its contribution in the development of lymphomas.
ISSN : 1871-5222 (impreso)
1875-6115 (online)
Disciplina: MEDICINA
DOI: 10.2174/187152221501150710125255
Derechos: Acceso abierto
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