Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/14022
Título : Histamine H4 receptor agonism induces antitumor effects in human T-cell lymphoma
Autor : Clauzure, Mariángeles 
Táquez Delgado, Mónica Alejandra 
Phillip, Jude M. 
Revuelta, Maria V. 
Cerchietti, Leandro 
Medina, Vanina Araceli 
Palabras clave : LINFOMA DE CÉLULAS TPANOBINOSTATHISTAMINAISOFORMAS H4RPROLIFERACIONAPOPTOSIS
Fecha de publicación : 2022
Editorial : Multidisciplinary Digital Publishing Institute
Cita : Clauzure, M. et al. Histamine H4 receptor agonism induces antitumor effects in human T-cell lymphoma [en línea]. International Journal of Molecular Sciences. 2022, 23 (3). doi: https://doi.org/10.3390/ijms23031378. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14022
Resumen : Abstract: The discovery of the human histamine H4 receptor (H4R) has contributed to our understanding of the role of histamine in numerous physiological and pathological conditions, including tumor development and progression. The lymph nodes of patients with malignant lymphomas have shown to contain high levels of histamine, however, less is known regarding the expression and function of the H4R in T-cell lymphoma (TCL). In this work we demonstrate the expression of H4R isoforms (mRNA and protein) in three human aggressive TCL (OCI-Ly12, Karpas 299, and HuT78). Histamine and specific H4R agonists (VUF8430 and JNJ28610244) significantly reduced cell viability in a dose-dependent manner (p < 0.05). The combined treatment with the H4R antagonist (JNJ7777120, 10 µM) reversed the effects of the H4R ligands. Importantly, we screened a drug repurposing library of 433 FDA-approved compounds (1 µM) in combination with histamine (10 µM) in Hut78 cells. Histamine produced a favorable antitumor effect with 18 of these compounds, including the histone deacetylase inhibitor panobinostat. Apoptosis, proliferation, and oxidative stress studies confirmed the antitumoral effects of the combination. We conclude that the H4R is expressed in TCL, and it is involved in histamine-mediated responses.
URI : https://repositorio.uca.edu.ar/handle/123456789/14022
ISSN : 1422-0067 (online)
1661-6596
Disciplina: MEDICINA
DOI: 10.3390/ijms23031378
Derechos: Acceso abierto
Appears in Collections:Artículos

Files in This Item:
File Description SizeFormat
histamine-h4-receptor-agonism.pdf2,34 MBAdobe PDFThumbnail
View/Open
Show full item record

Page view(s)

64
checked on Apr 16, 2024

Download(s)

30
checked on Apr 16, 2024

Google ScholarTM

Check


Altmetric


This item is licensed under a Creative Commons License Creative Commons