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Título : | Oculomotor abnormalities during reading in the offspring of late-onset alzheimer’s disease | Autor : | Fernández, Gerardo González, Ana Paula Abulafia, Carolina Andrea Fiorentini, Leticia Agamennoni, Osvaldo Guinjoan, Salvador M. |
Palabras clave : | ENFERMEDAD DE ALZHEIMER; HIJOS; DETERIORO COGNITIVO; OJOS; LECTURA; DETERIORO OCULOMOTOR | Fecha de publicación : | 2022 | Editorial : | Bentham Science Publishers | Cita : | Fernández, G. et al. Oculomotor abnormalities during reading in the offspring of late-onset alzheimer’s disease [en línea]. Current Alzheimer Research. 2022, 20 (1-2). doi: 10.2174/1567205019666220413075840. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14021 | Resumen : | Abstract: Introduction: Eye movement patterns during reading are well defined and documented. Each eye movement ends up in a fixation point, which allows the brain to process the incoming information and program the following saccade. In this work, we investigated whether eye movement alterations during a reading task might be already present in middle-aged, cognitively normal offspring of late-onset Alzheimer’s disease (O-LOAD). Methods: 18 O-LOAD and 18 age-matched healthy individuals with no family history of LOAD participated in the study. Participants were seated in front of a 20-inch LCD monitor, and single sentences were presented on it. Eye movements were recorded with an eye tracker with a sampling rate of 1000 Hz. Results: Analysis of eye movements during reading revealed that O-LOAD displayed more fixations, shorter saccades, and shorter fixation durations than controls. Conclusion: The present study shows that O-LOAD experienced alterations in their eye movements during reading. O-LOAD eye movement behavior could be considered an initial sign of oculomotor impairment. Hence, the evaluation of eye movement during reading might be a useful tool for monitoring well-defined cognitive resources. | URI : | https://repositorio.uca.edu.ar/handle/123456789/14021 | ISSN : | 1567-2050 1875-5828 (online) |
Disciplina: | MEDICINA | DOI: | 10.2174/1567205019666220413075840 | Derechos: | Acceso abierto |
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