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Título : Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease
Autor : Duarte Abritta, Bárbara 
Sánchez, Stella Maris 
Abulafia, Carolina Andrea 
Gustafson, Deborah R. 
Vázquez, Silvia 
Sevlever, Gustavo 
Castro, Mariana N. 
Fiorentini, Leticia 
Villarreal, Mirta F. 
Guinjoan, Salvador M. 
Fecha de publicación : 2021
Editorial : Elsevier
Cita : Duarte Abritta, B. et al. Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease [en línea]. Postprint del artículo publicado en: Psychiatry Research: Neuroimaging. 2021, 316. doi: Disponible en:
Resumen : Abstract: A traditional hallmark of cognitive impairment associated with late-onset Alzheimer´s disease (LOAD) is episodic memory impairment. However, early alterations have been identified in brain regions associated with executive function in asymptomatic, middle-age offspring of patients with LOAD (O-LOAD) compared to those with no family history. We hypothesized that executive function among O-LOAD would correlate with structural and amyloid brain imaging differently from those without a family history of LOAD (control subjects, CS). Executive function, cortical thickness, and in-vivo Aβ deposits were quantified in 30 O-LOAD and 25 CS. Associations were observed among O-LOAD only. Cortical thickness in the left lateral orbitofrontal cortex was positively associated with Design Fluency. The Stroop Color and Word Test, correlated positively with right rostral mid-frontal cortex thickness. Trails Making Test-B was inversely related to left medial orbitofrontal thickness. Tower of London total time was positively associated with β-amyloid deposition in the right precuneus. These results support previous evidence that early executive dysfunction might reflect subtle, early changes in persons at risk of LOAD and suggests that executive function alterations deserve further exploration in the LOAD literature.
ISSN : 0925-4927
Disciplina: MEDICINA
DOI: 10.1016/j.pscychresns.2021.111342
Derechos: Acceso abierto
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