Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/13665
Título : Can melatonin be a potential “silver bullet” in treating covid-19 patients?
Autor : Cardinali, Daniel Pedro 
Brown, Gregory M. 
Pandi Perumal, Seithikurippu R. 
Palabras clave : ENVEJECIMIENTOVACUNACIONCOVID-19SARS-CoV-2DIABETESINFLAMACIONSINDROME METABOLICOMELATONINADETERIORO COGNITIVONEURODEGENERACIONESTRES OXIDATIVOSISTEMA RENINA-ANGIOTENSINA
Fecha de publicación : 2020
Editorial : Multidisciplinary Digital Publishing Institute
Cita : Cardinali, D.P., Brown, G. M., Pandi Perumal, S. R. Can melatonin be a potential “silver bullet” in treating covid-19 patients? [en línea]. Diseases. 2020, 8 (4). doi: 10.3390/diseases8040044. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13665
Resumen : Abstract: The therapeutic potential of melatonin as a chronobiotic cytoprotective agent to counteract the consequences of COVID-19 infections has been advocated. Because of its wide-ranging effects as an antioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could be unique in impairing the consequences of SARS-CoV-2 infection. Moreover, indirect evidence points out to a possible antiviral action of melatonin by interfering with SARS-CoV-2/angiotensin-converting enzyme 2 association. Melatonin is also an effective chronobiotic agent to reverse the circadian disruption of social isolation and to control delirium in severely affected patients. As a cytoprotector, melatonin serves to combat several comorbidities such as diabetes, metabolic syndrome, and ischemic and non-ischemic cardiovascular diseases, which aggravate COVID-19 disease. In view of evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. Since melatonin is an effective means to control cognitive decay in minimal cognitive impairment, its therapeutic significance for the neurological sequels of SARS-CoV-2 infection should be considered. Finally, yet importantly, exogenous melatonin can be an adjuvant capable of augmenting the efficacy of anti-SARS-CoV-2 vaccines. We discuss in this review the experimental evidence suggesting that melatonin is a potential “silver bullet” in the COVID 19 pandemic.
URI : https://repositorio.uca.edu.ar/handle/123456789/13665
ISSN : 2079-9721
Disciplina: MEDICINA
DOI: 10.3390/diseases8040044
Derechos: Acceso abierto
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