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Título : Structural and functional motor-network disruptions predict selective action-concept deficits: Evidence from frontal lobe epilepsy
Autor : Moguilner, Sebastian 
Birba, Agustina 
Fino, Daniel 
Huetagoyena, Celeste 
Otoya, Raúl 
Tirapu, Viviana 
Cremaschi, Fabián 
Sedeño, Lucas 
Ibáñez, Agustín 
García, Adolfo M. 
Isoardi, Roberto 
Palabras clave : EPILEPSIAMACHINE LEARNINGCONDUCTAFUNCIONES MOTORAS
Fecha de publicación : 2021
Editorial : Elsevier
Cita : Moguilner, S., et al. Structural and functional motor-network disruptions predict selective action-concept deficits: Evidence from frontal lobe epilepsy [en línea]. Cortex. 2021, 144 doi:10.1016/j.cortex.2021.08.003 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/13411
Resumen : Abstract: Built on neurodegenerative lesions models, the disrupted motor grounding hypothesis (DMGH) posits that motor-system alterations selectively impair action comprehension. However, major doubts remain concerning the dissociability, neural signatures, and etiological generalizability of such deficits. Few studies have compared action-concept outcomes between disorders affecting and sparing motor circuitry, and none has examined their multimodal network predictors via data-driven approaches. Here, we first assessed action- and object-concept processing in patients with frontal lobe epilepsy (FLE), patients with posterior cortex epilepsy (PCE), and healthy controls. Then, we examined structural and functional network signatures via diffusion tensor imaging and resting-state connectivity measures. Finally, we used these measures to predict behavioral performance with an XGBoost machine learning regression algorithm. Relative to controls, FLE (but not PCE) patients exhibited selective action-concept deficits together with structural and functional abnormalities along motor networks. The XGBoost model reached a significantly large effect size only for action-concept outcomes in FLE, mainly predicted by structural (cortico-spinal tract, anterior thalamic radiation, uncinate fasciculus) and functional (M1- parietal/supramarginal connectivity) motor networks. These results extend the DMGH, suggesting that action-concept deficits are dissociable markers of frontal/motor (relative to posterior) disruptions, directly related to the structural and functional integrity of motor networks, and traceable beyond canonical movement disorders.
URI : https://repositorio.uca.edu.ar/handle/123456789/13411
ISSN : 0010-9452
Disciplina: PSICOLOGIA
DOI: 10.1016/j.cortex.2021.08.003
Derechos: Acceso abierto. 24 meses de embargo
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