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Título : | Antiproliferative activity of aqueous and polyphenol-rich extracts of Larrea divaricata Cav. upon a melanoma cell line | Autor : | Martino, Renzo Barreiro Arcos, María Laura Peralta, Ignacio Marrassini, Carla Saint Martin, Elina Malén Cogoi, Laura Cremaschi, Graciela A. Alonso, María Rosario Anesini, Claudia |
Palabras clave : | MELANOMA; FITOTERAPIA; APOPTOSIS; METASTASIS | Fecha de publicación : | 2021 | Editorial : | Taylor and Francis | Cita : | Martino, R., et al. Antiproliferative activity of aqueous and polyphenol-rich extracts of Larrea divaricata Cav. upon a melanoma cell line [en línea]. Natural Product Research, 2021. doi:10.1080/14786419.2021.1980789. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/12861 | Resumen : | Abstract: Most of the deaths from skin cancer are caused by melanoma, a malignancy in which STAT3 plays a crucial role. The inhibition of STAT3 is considered a potential target to induce cell death, tumor regression and metastasis inhibition. The objective of this work was to evaluate the activity of the aqueous extract of Larrea divaricata (Aq), a fraction rich in polyphenols (EA),and the isolated compound quercetin-3-methyl ether (Q3ME) on B16F10 melanoma cells. The effects of Aq, EA and Q3ME were assessed on B16F10 cells by determining the proliferation, viability, apoptosis induction and the expression and phosphorylation of STAT3. The phytochemical composition of the extracts was determined by High Performance Liquid Chromatography. Aq, EA and Q3ME presented antiproliferative activity on B6F10 cells through p-STAT3 inhibition and early and late apoptosis induction (EC50 EA= ≤0.1 μg/ml; Aq= 316±30 μg/ml; Q3ME= <0.1 μg/ml). L. divaricata could be considered for the development of adjuvant phytotherapies in melanoma treatment. | URI : | https://repositorio.uca.edu.ar/handle/123456789/12861 | ISSN : | 1478-6419 (impreso) 1478-6427 (online) |
Disciplina: | MEDICINA | DOI: | 10.1080/14786419.2021.1980789 | Derechos: | Acceso abierto. 12 meses de embargo |
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