Por favor, use este identificador para citar o enlazar este ítem: https://repositorio.uca.edu.ar/handle/123456789/11625
Título : Effects of angiotensin type 1 receptor antagonists on Parkinson's disease progression : an exploratory study in the PPMI database
Autor : Udovin, Lucas Daniel 
Otero Losada, Matilde 
Bordet, Sofía 
Chevalier, Guenson 
Quarracino, Cecilia 
Capani, Francisco 
Pérez Lloret, Santiago 
Palabras clave : ESTUDIO DE CASOSENFERMEDAD DE PARKINSONENFERMEDADES NEURODEGENERATIVASNEUROPROTECCION
Fecha de publicación : 2021
Editorial : Elsevier
Cita : Udovin, L. D., et al. Effects of angiotensin type 1 receptor antagonists on Parkinson's disease progression : an exploratory study in the PPMI database [en línea]. Postprint del artículo publicado en: Parkinsonism Relat Disord . 2021, 86. doi:10.1016/j.parkreldis.2021.03.007. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/11625
Resumen : Abstract: Introduction. We explored the potential clinical effects of angiotensin-II AT1 receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) in patients from the Parkinson’s Progress Marker Initiative (PPMI) study database. Methods. We included 423 newly diagnosed PD patients, free from antiparkinsonian treatment, from the PPMI. We compared the proportion of patients starting on L-DOPA during the first year of follow-up, and the changes in MDS-UPDRS total score and sub-scores during the first five follow-up years for patients exposed or not to ARBs or ACEIs. Results. Treatment with ARBs did not affect the proportion of patients on L-DOPA during the first year (adjusted OR, 95% CI= 0.26, 0.03-2.18, N.S.) while reduced MDS-UPDRS total score (0.85, 0.76-0.95, p<0.01). Patients treated with ACEIs experienced no changes in either measure. Conclusions. These results show potential signals for a beneficial effect with ARBs. Further clinical trials are warranted.
URI : https://repositorio.uca.edu.ar/handle/123456789/11625
ISSN : 1353-8020
Disciplina: MEDICINA
DOI: 10.1016/j.parkreldis.2021.03.007
Derechos: Acceso abierto. 12 meses de embargo
Aparece en las colecciones: Artículos

Ficheros en este ítem:
Fichero Descripción Tamaño Formato
effects-angiotensin-1-type-receptor.pdf451,54 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro Dublin Core completo del ítem

Visualizaciones de página(s)

104
comprobado en 28-mar-2024

Descarga(s)

173
comprobado en 28-mar-2024

Google ScholarTM

Consultar


Altmetric


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons