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Título : Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice
Autor : Juárez, Yamila R. 
Quiroga, Sofía 
Prochnik, Andrés 
Wald, Miriam Ruth 
Tellechea, Mariana L. 
Genaro, Ana María 
Burgueño, Adriana Laura 
Fecha de publicación : 2020
Editorial : Cambridge University Press
Cita : Juárez Y.R., Quiroga S., Prochnik A., Wald M., Tellechea M.L., Genaro A.M., Burgueño A.L. Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c miceJ [en línea]. Postprint del artículo publicado en: Journal of Developmental Origins of Health and Disease. 2020. Doi: 10.1017/ S2040174420000987. Disponible en:
Resumen : Abstract: Prenatal insults during fetal development result in increased likelihood of developing chronic disease. Obesity, the biggest risk factor for the development of metabolic disease, is affected by several genetic and environmental factors. High-fat diet (HFD) consumption is usually linked with the development of obesity. The main goal of this study was to analyze the impact of the exposure to a HFD in prenatally stressed animals. For this purpose, we subjected pregnant BALB/c mice to restraint stress for 2 h a day between gestational day (GD) 14 and GD 21. Prenatally stressed and control offspring of both sexes were postnatally exposed to a HFD for 24 weeks. We found that prenatal stress (PS) per se produced disturbances in males such as increased total blood cholesterol and triglycerides, with a decrease in mRNA expression of sirtuin-1.When these animals were fed a HFD, we observed a rise in glucose and insulin levels and an increase in visceral adipose tissue gene expression of leptin, resistin, and interleukin-1 beta. Although females proved to be more resilient to PS consequences, when they were fed a HFD, they showed significant metabolic impairment. In addition to the changes observed in males, females also presented an increase in body weight and adiposity and a rise in cholesterol levels.
ISSN : 2040-1752 (en línea)
Disciplina: MEDICINA
DOI: 10.1017/ S2040174420000987
Derechos: Acceso abierto. 6 meses de embargo
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