Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/11468
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dc.contributor.authorSvetaz, Laura A.es
dc.contributor.authorDi Liberto, Melina G.es
dc.contributor.authorZanardi, María M.es
dc.contributor.authorSuárez, Alejandra G.es
dc.contributor.authorZacchino, Susana A.es
dc.date.accessioned2021-05-03T13:24:59Z-
dc.date.available2021-05-03T13:24:59Z-
dc.date.issued2014-
dc.identifier.citationSvetaz, L. A., Di Liberto, M. G., Zanardi, M. M., Suárez, A. G., Zacchino, S.A. Efficient production of the flavoring agent zingerone and of both (r)- and (s)-zingerols via green fungal biocatalysis: comparative antifungal activities between enantiomers [en línea]. International Journal of Molecular Sciences. 2014 (15). Disponible en: https://repositorio.uca.edu.ar/handle/123456789/11468es
dc.identifier.issn1422-0067-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/11468-
dc.description.abstractAbstract: Zingerone (1) and both chiral forms of zingerol (2) were obtained from dehydrozingerone (3) by biotransformation with filamentous fungi. The bioconversion of 3 with A. fumigatus, G. candidum or R. oryzae allowed the production of 1 as the sole product at 8 h and in 81%–90% at 72 h. In turn, A. flavus, A. niger, C. echinulata, M. circinelloides and P. citrinum produced 1 at 8 h, but at 72 h alcohol 2 was obtained as the major product (74%–99%). Among them, A. niger and M. circinelloides led to the anti-Prelog zingerol (R)-2 in only one step with high conversion rates and ee. Instead, C. echinulata and P. citrinum allowed to obtain (S)-2 in only one step, with high conversion rates and ee. Both chiral forms of 2 were tested for antifungal properties against a panel of clinically important fungi, showing that (R)-, but not (S)-2 possessed antifungal activity.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.rightsAcceso abierto*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceInternational Journal of Molecular Sciences vol.15, 2014es
dc.subjectANTIFUNGICOes
dc.subjectHONGOSes
dc.titleEfficient production of the flavoring agent zingerone and of both (r)- and (s)-zingerols via green fungal biocatalysis: comparative antifungal activities between enantiomerses
dc.typeArtículoes
dc.identifier.doi10.3390/ijms151222042-
uca.disciplinaQUIMICAes
uca.issnrd1es
uca.affiliationFil: Svetaz, Laura A. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentinaes
uca.affiliationFil: Di Liberto, Melina G. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentinaes
uca.affiliationFil: Zanardi, María M. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas, ; Argentinaes
uca.affiliationFil: Zanardi, María M. Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina. Instituto de Química Rosario; Argentinaes
uca.affiliationFil: Suárez, Alejandra G. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas, ; Argentinaes
uca.affiliationFil: Suárez, Alejandra G. Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina. Instituto de Química Rosario; Argentinaes
uca.affiliationFil: Zacchino, Susana A. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentinaes
uca.versionpublishedVersiones
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
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