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Título : | Long-term effects of hypoxia-reoxygenation on thioredoxins in rat central nervous system | Autor : | Otero Losada, Matilde Canepa, Leonardo Udovin, Lucas Daniel Kobiec, Tamara Toro-Urrego, Nicolás Kölliker Frers, Rodolfo Capani, Francisco |
Palabras clave : | HIPOXIA; ISQUEMIA; SISTEMA NERVIOSO CENTRAL; PROTEINAS | Fecha de publicación : | 2019 | Editorial : | Bentham Science Publisher | Cita : | Otero Losada, M., Canepa, L., Udovin, L. D., Kobiec, T., Toro-Urrego, N., Kölliker Frers, R., Capani, F. Long-term effects of hypoxia-reoxygenation on thioredoxins in rat central nervous system [en línea] Postprint del artículo publicado en Current Pharmaceutical Design. 2019, 25(46). Doi: 10.2174/1381612825666191211111926. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/11346 | Resumen : | Abstract: Oxidative stress induced by the oxidative pathway dysregulation following ischemia/reperfusion has been proposed as an important cause of neuronal death and brain damage. The proteins of the thioredoxin (Trx) family are crucial mediators of protein function regulating the intracellular hydrogen peroxide levels and redoxsensitive post-translational protein changes. This study evaluates the long-term effects of common carotid artery ligation-induced ischemia/reperfusion on the protein expression and distribution of fourteen members of the Trx family and related proteins (Grx1, Grx2, Grx3, Grx5, Prx1, Prx2, Prx3, Prx4, Prx5, Prx6, Trx1, Trx2, TrxR1, TrxR2) in the most hypoxia susceptible rat brain areas, namely, cerebellum, corpus striatum, and the hippocampus. The thioredoxin proteins displayed a complex, cell-type, and tissue-specific expression pattern following ischemia/reperfusion. | URI : | https://repositorio.uca.edu.ar/handle/123456789/11346 | ISSN : | 1381-6128 (impreso) 1873-4286 (en línea) |
Disciplina: | PSICOLOGIA | DOI: | 10.2174/1381612825666191211111926 | Derechos: | Acceso abierto |
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