Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/10846
Título : Central nervous system targets and routes for SARS-CoV-2 : current views and new hypotheses
Autor : Barrantes, Francisco José 
Palabras clave : MEDICINACOVID-19SARS-CoV-2PANDEMIAINFECCIONESVIRUS
Fecha de publicación : 2020
Editorial : American Chemical Society
Cita : Barrantes FJ. Central nervous system targets and routes for SARS-CoV-2 : current views and new hypotheses [en línea]. ACS chemical neuroscience. 2020, 11(18). Disponible en: https://repositorio.uca.edu.ar/handle/123456789/10846
Resumen : Abstract: As the coronavirus disease 2019 (COVID-19) pandemic unfolds, neurological signs and symptoms reflect the involvement of targets beyond the primary lung affectation. The etiological agent of COVID-19, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibits neurotropism for central and peripheral nervous systems. Various infective mechanisms and paths can be exploited by the virus to reach the central nervous system, some of which bypass the blood-brain-barrier; others alter its integrity. Numerous studies have established beyond doubt that the membrane-bound metalloprotease angiotensin-converting enzyme 2 (ACE2) performs the role of SARS-CoV-2 host-cell receptor. Histochemical studies and more recently transcriptomics of mRNA have dissected the cellular localization of the ACE2 enzyme in various tissues, including the central nervous system. Epithelial cells lining the nasal mucosae, the upper respiratory tract and the oral cavity, bronchoalveolar cells type II in the pulmonary parenchyma and intestinal enterocytes display ACE2 binding sites at their cell surfaces, making these epithelial mucosae the most likely viral entry points. Neuronal and glial cells and endothelial cells in the central nervous system also express ACE2. This short review analyzes the known entry points and routes followed by the SARS-CoV-2 to reach the central nervous system, and postulates new hypothetical pathways stemming from the enterocytes lining the intestinal lumen.
URI : https://repositorio.uca.edu.ar/handle/123456789/10846
ISSN : 1948-7193
Disciplina: MEDICINA
DOI: 10.1021/acschemneuro.0c00434
Derechos: Acceso abierto
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