Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/9437
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dc.contributor.authorMartinel Lamas, Diego J.es
dc.contributor.authorRivera, Elena S.es
dc.contributor.authorMedina, Vanina Aracelies
dc.date.accessioned2020-02-19T00:33:10Z-
dc.date.available2020-02-19T00:33:10Z-
dc.date.issued2015-
dc.identifier.citationMartinel Lamas, D. J., Rivera, E. S., Medina, V. A. Histamine H4 receptor : insights into a potential therapeutic target in breast cancer [en línea]. Frontiers in Bioscience. 2015, 7(1). doi:10.2741/420. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9437es
dc.identifier.issn1945-0516 (impreso)-
dc.identifier.issn1945-0524 (on line)-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/9437-
dc.description.abstractAbstract: Breast cancer is the second most common cancer worldwide, and the leading cause of cancer death in women. Several studies underlined the critical role of histamine in breast cancer development and progression. This review addresses the latest evidence regarding the involvement of histamine and histamine receptors in breast cancer, focusing particularly in the histamine H4 receptor (H4R). Histamine concentration in breast cancer tissues was found to be higher than that in normal tissues of healthy controls by means of an increase in the activity of histidine decarboxylase (HDC), the enzyme involved in histamine production. The expression of H4R in different experimental models and human biopsies, the associated biological responses, as well as the in vivo treatment of experimental tumors with H4R ligands is reviewed. Evidence demonstrates that the H4R exhibits a key role in histamine-mediated biological processes such as cell proliferation, senescence and apoptosis in breast cancer. The polymorphisms of the H4R and HDC genes and their association with breast cancer risk and malignancy reinforce the critical (patho) physiological role of H4R in breast cancer. In addition, H4R agonists display anti-tumor effects in vivo in a triple negative breast cancer model. The findings support the exploitation of the H4R as a molecular target for breast cancer drug development.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.rightsAcceso Abierto*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.sourceFrontiers in Bioscience. 2015, 7(1)es
dc.subjectCANCER DE MAMAes
dc.subjectHISTAMINAes
dc.subjectTRATAMIENTO MEDICOes
dc.subjectONCOLOGIAes
dc.titleHistamine H4 receptor : insights into a potential therapeutic target in breast canceres
dc.typeArtículoes
dc.identifier.doi10.2741/420-
dc.identifier.pmid25961682-
uca.disciplinaMEDICINAes
uca.issnrd1es
uca.affiliationFil: Martinel Lamas, Diego J. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentinaes
uca.affiliationFil: Martinel Lamas, Diego J. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentinaes
uca.affiliationFil: Martinel Lamas, Diego J. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Rivera, Elena S. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentinaes
uca.affiliationFil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentinaes
uca.affiliationFil: Medina, Vanina Araceli. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentinaes
uca.affiliationFil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.versionpublishedVersiones
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptLaboratorio de Biología Tumoral e Inflamación-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Biología Tumoral e Inflamación-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.orcid0000-0002-7767-0729-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
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