Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/9301
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dc.contributor.authorPeralta, Ignacioes
dc.contributor.authorMarrassini, Carlaes
dc.contributor.authorBarreiro Arcos, María Lauraes
dc.contributor.authorCremaschi, Graciela A.es
dc.contributor.authorAnesini, Claudiaes
dc.date.accessioned2019-12-17T23:43:06Z-
dc.date.available2019-12-17T23:43:06Z-
dc.date.issued2019-
dc.identifier.citationPeralta, I., et al. Larrea divaricata Cav. aqueous extract and nordihydroguariaretic acid modulate oxidative stress in submandibular glands of diabetic rats: a buccal protective in diabetes [en línea]. BMC Complementary and Alternative Medicine. 2019, (19)227. doi: 10.1186/s12906-019-2636-z. Disponible en:https://repositorio.uca.edu.ar/handle/123456789/9301es
dc.identifier.issn1472-6882 (en línea)-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/9301-
dc.description.abstractAbstract: Background. Oxidative stress is an imbalance between the levels of reactive oxygen species (ROS), reactive nitrogen species (RNS) and endogenous antioxidants. The aetiology and pathogenesis of several oral diseases are attributed to this process. The antioxidant enzymes secreted in the saliva by submandibular glands maintain oral health through the scavenging of ROS. The objective of this work was to study the capacity of an aqueous extract of L. divaricata (AE), and its majority compound, nordihydroguariaretic acid (NDGA), to modulate the pro-oxidant/antioxidant status in submandibular glands in a model of oxidative stress induced by streptozotocin (STZ) in rats. Methods. To induce oxidative stress with STZ, a group of animals was treated i.p. with 1 X PBS (control group) and other group was injected i.p. once with STZ (60 mg/kg). Ten days after the treatment, blood samples were taken from the tail vain to determine the glucose levels. Animals with glucose values ≥300 mg/ml were selected. The submandibular glands of control and STZ treated animals were incubated with either the AE (500 μg/ml) or with NDGA (1.5 μg/ml), and the content of malondialdehyde (MDA), protein carbonyl groups, ROS and RNS, and the activity and expression of peroxidase (Px), superoxide dismutase (SOD) and inducible nitric oxide synthase (iNOS) were assayed. Results AE decreased the levels of MDA (P < 0.01) and protein carbonyl groups (P < 0.05), and modulated the levels of ROS such as hydrogen peroxide (H2O2)(P < 0.01), superoxide anion (O2.-) (P < 0.05) and nitric oxide (NO) (P < 0.05) in relation to the modulation of Px and iNOS expression. NDGA was found to be involved in these effects. Conclusions. The antioxidant activity of the AE in the submandibular glands would allow the maintenance of the antioxidant pool to prevent oral oxidative diseases.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherBMCes
dc.rightsAcceso abierto*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceBMC Complementary and Alternative Medicine. 2019, (19)227es
dc.subjectESTRES OXIDATIVOes
dc.subjectANTIOXIDANTESes
dc.subjectESTOMATOLOGIAes
dc.subjectGLANDULAS SALIVALESes
dc.subjectENZIMASes
dc.subjectSALUD BUCALes
dc.subjectDIABETESes
dc.titleLarrea divaricata Cav. aqueous extract and nordihydroguariaretic acid modulate oxidative stress in submandibular glands of diabetic rats : a buccal protective in diabeteses
dc.typeArtículoes
dc.identifier.doi10.1186/s12906-019-2636-z-
dc.identifier.pmid31438933-
uca.disciplinaMEDICINAes
uca.issnrd1es
uca.affiliationFil: Peralta, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Peralta, Ignacio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentinaes
uca.affiliationFil: Peralta, Ignacio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentinaes
uca.affiliationFil: Marrassini, Carla. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Marrassini, Carla. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentinaes
uca.affiliationFil: Marrassini, Carla. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentinaes
uca.affiliationFil: Barreiro Arcos, María Laura. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentinaes
uca.affiliationFil: Barreiro Arcos, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Cremaschi, Graciela A. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentinaes
uca.affiliationFil: Cremaschi, Graciela A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Anesini, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Anesini, Claudia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentinaes
uca.affiliationFil: Anesini, Claudia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentinaes
uca.versionpublishedVersiones
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.languageiso639-1en-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Neuroinmunomodulación y Oncología Molecular-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Neuroinmunomodulación y Oncología Molecular-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.orcid0000-0002-7976-9183-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
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