GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2

Li, Zhi-Wei; Sun, Beicheng; Gong, Ting; Guo, Sheng; Zhang, Jianhua; Wang, Junlong; Sugawara, Atsushi; Jiang, Meisheng; Yan, Junjun; Gurary, Alexandra; Zheng, Xin; Gao, Bifeng; Xiao, Shu-Yuan; Chen, Wenlian; Ma, Chi; Farrar, Christine; Zhu, Chenjun; Chan, Owen T. M.; Xin, Can; Winnicki, Andrew; Winnicki, John; Tang, Mingxin; Park, Ryan; Winnicki, Mary; Diener, Katrina; Wang, Zhanwei; Liu, Qicai; Chu, Catherine H.; Arter, Zhaohui L.; Yue, Peibin; Alpert, Lindsay; Hui, George S.; Fei, Peiwen; Turkson, James; Yang, Wentian; Wu, Guangyu; Tao, Ailin; Ramos, Joe W.; Moisyadi, Stefan; Holcombe, Randall F.; Jia, Wei; Birnbaumer, Lutz; Zhou, Xiqiao; Chu, Wen-Ming

Por favor, use este identificador para citar o enlazar este ítem: https://repositorio.uca.edu.ar/handle/123456789/9271

Campo DC	Valor	Lengua/Idioma
dc.contributor.author	Li, Zhi-Wei	es
dc.contributor.author	Sun, Beicheng	es
dc.contributor.author	Gong, Ting	es
dc.contributor.author	Guo, Sheng	es
dc.contributor.author	Zhang, Jianhua	es
dc.contributor.author	Wang, Junlong	es
dc.contributor.author	Sugawara, Atsushi	es
dc.contributor.author	Jiang, Meisheng	es
dc.contributor.author	Yan, Junjun	es
dc.contributor.author	Gurary, Alexandra	es
dc.contributor.author	Zheng, Xin	es
dc.contributor.author	Gao, Bifeng	es
dc.contributor.author	Xiao, Shu-Yuan	es
dc.contributor.author	Chen, Wenlian	es
dc.contributor.author	Ma, Chi	es
dc.contributor.author	Farrar, Christine	es
dc.contributor.author	Zhu, Chenjun	es
dc.contributor.author	Chan, Owen T. M.	es
dc.contributor.author	Xin, Can	es
dc.contributor.author	Winnicki, Andrew	es
dc.contributor.author	Winnicki, John	es
dc.contributor.author	Tang, Mingxin	es
dc.contributor.author	Park, Ryan	es
dc.contributor.author	Winnicki, Mary	es
dc.contributor.author	Diener, Katrina	es
dc.contributor.author	Wang, Zhanwei	es
dc.contributor.author	Liu, Qicai	es
dc.contributor.author	Chu, Catherine H.	es
dc.contributor.author	Arter, Zhaohui L.	es
dc.contributor.author	Yue, Peibin	es
dc.contributor.author	Alpert, Lindsay	es
dc.contributor.author	Hui, George S.	es
dc.contributor.author	Fei, Peiwen	es
dc.contributor.author	Turkson, James	es
dc.contributor.author	Yang, Wentian	es
dc.contributor.author	Wu, Guangyu	es
dc.contributor.author	Tao, Ailin	es
dc.contributor.author	Ramos, Joe W.	es
dc.contributor.author	Moisyadi, Stefan	es
dc.contributor.author	Holcombe, Randall F.	es
dc.contributor.author	Jia, Wei	es
dc.contributor.author	Birnbaumer, Lutz	es
dc.contributor.author	Zhou, Xiqiao	es
dc.contributor.author	Chu, Wen-Ming	es
dc.date.accessioned	2019-12-12T18:19:19Z	-
dc.date.available	2019-12-12T18:19:19Z	-
dc.date.issued	2019	-
dc.identifier.citation	Li, Z. et al. GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2 [en línea]. Gastroenterology. 2019, 156(8). doi:10.1053/j.gastro.2019.02.040 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9271	es
dc.identifier.issn	0016-5085	-
dc.identifier.uri	https://repositorio.uca.edu.ar/handle/123456789/9271	-
dc.description.abstract	Abstract: Interleukin 6 (IL6) and tumor necrosis factor contribute to the development of colitis-associated cancer (CAC). We investigated these signaling pathways and the involvement of G protein subunit alpha i1 (GNAI1), GNAI2, and GNAI3 in the development of CAC in mice and humans. GNAI1;3 suppresses DSS-plus-AOM–induced colon tumor development in mice, whereas expression of GNAI2 in CD11c+ cells and IL6 in CD4+/CD11b+ DCs appears to promote these effects. Strategies to induce GNAI1;3, or block GNAI2 and IL6, might be developed for the prevention or therapy of CAC in patients.	es
dc.format	application/pdf	es
dc.language.iso	eng	es
dc.publisher	Elsevier	es
dc.rights	Acceso abierto	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	*
dc.source	Gastroenterology. 2019, 156(8)	es
dc.subject	CANCER	es
dc.subject	TUMORES	es
dc.subject	COLITIS	es
dc.subject	CARCINOGENESIS	es
dc.title	GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2	es
dc.type	Artículo	es
dc.identifier.doi	10.1053/j.gastro.2019.02.040	-
dc.identifier.pmid	30836096	-
uca.disciplina	MEDICINA	es
uca.issnrd	1	es
uca.affiliation	Fil: Li, Zhi-Wei. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Sun, Beicheng. Nanjing University Medical School. The Affiliated Drum Tower Hospital. Department of Hepatobiliary Surgery; China	es
uca.affiliation	Fil: Gong, Ting. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Guo, Sheng. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Guo, Sheng. Shanghai Jiao Tong University. Shanghai Children’s Hospital. Department of Endocrine, Genetics and Metabolism; China	es
uca.affiliation	Fil: Zhang, Jianhua. University of Hawaii. Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Zhang, Jianhua. Shanghai Jiao Tong University. School of Medicine. Xinhua Hospital. Department of Pediatrics; China	es
uca.affiliation	Fil: Wang, Junlong. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Sugawara, Atsushi. University of Hawaii. John A. Burns School of Medicine. Institute for Biogenesis Research; Estados Unidos	es
uca.affiliation	Fil: Jiang, Meisheng. University of California. Department of Molecular and Medical Pharmacology; Estados Unidos	es
uca.affiliation	Fil: Yan, Junjun. Nanjing Medical University. The First Affiliated Hospital. Department of Gastroenterology; China	es
uca.affiliation	Fil: Gurary, Alexandra. University of Hawaii. John A. Burns School of Medicine. Department of Tropical Medicine, Medical Microbiology, and Pharmacology; Estados Unidos	es
uca.affiliation	Fil: Zheng, Xin. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Gao, Bifeng. University of Colorado Anschutz Medical Campus. Department of Medicine; Estados Unidos	es
uca.affiliation	Fil: Xiao, Shu-Yuan. Wuhan University. Zhongnan Hospital. Department of Pathology; China	es
uca.affiliation	Fil: Xiao, Shu-Yuan. University of Chicago. Department of Pathology; Estados Unidos	es
uca.affiliation	Fil: Chen, Wenlian. University of Hawaii. Cancer Center. Epidemiology Program; Estados Unidos	es
uca.affiliation	Fil: Ma, Chi. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Farrar, Christine. University of Hawaii Cancer Center. The Microscopy, Imaging, and Flow Cytometry Shared Resource; Estados Unidos	es
uca.affiliation	Fil: Zhu, Chenjun. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Chan, Owen T. M. University of Hawaii Cancer Center. Pathology Core; Estados Unidos	es
uca.affiliation	Fil: Xin, Can. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Winnicki, Andrew. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Winnicki, John. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Tang, Mingxin. University of Hawaii. John A. Burns School of Medicine. Center for Cardiovascular Research; Estados Unidos	es
uca.affiliation	Fil: Park, Ryan. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Winnicki, Mary. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Diener, Katrina. University of Colorado Anschutz Medical Campus. Department of Medicine; Estados Unidos	es
uca.affiliation	Fil: Wang, Zhanwei. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Liu, Qicai. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Liu, Qicai. Southern Medical University. Zhujiang Hospital. Department of Cardiology and Heart Center; China	es
uca.affiliation	Fil: Chu, Catherine H. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Arter, Zhaohui L. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Yue, Peibin. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Alpert, Lindsay. University of Chicago. Department of Pathology; Estados Unidos	es
uca.affiliation	Fil: Hui, George S. University of Hawaii. John A. Burns School of Medicine. Department of Tropical Medicine, Medical Microbiology, and Pharmacology; Estados Unidos	es
uca.affiliation	Fil: Fei, Peiwen. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Turkson, James. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Yang, Wentian. Brown University. Alpert Medical School. Rhode Island Hospital	es
uca.affiliation	Fil: Wu, Guangyu. Augusta University. Department of Pharmacology and Toxicology; Estados Unidos	es
uca.affiliation	Fil: Tao, Ailin. Guangzhou Medical University. Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology. The State Key Laboratory of Respiratory Disease. The Second Affiliated Hospital; China	es
uca.affiliation	Fil: Ramos, Joe W. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Moisyadi, Stefan. University of Hawaii. John A. Burns School of Medicine. Institute for Biogenesis Research; Estados Unidos	es
uca.affiliation	Fil: Holcombe, Randall F. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Jia, Wei. University of Hawaii Cancer Center. Epidemiology Program; Estados Unidos	es
uca.affiliation	Fil: Birnbaumer, Lutz. Research Triangle Park. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos	es
uca.affiliation	Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina	es
uca.affiliation	Fil: Zhou, Xiqiao. Nanjing Medical University. The First Affiliated Hospital. Department of Gastroenterology; China	es
uca.affiliation	Fil: Chu, Wen-Ming. University of Hawaii Cancer Center. Cancer Biology Program; Estados Unidos	es
uca.affiliation	Fil: Chu, Wen-Ming. Guangzhou Medical University. Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology. The State Key Laboratory of Respiratory Disease. The Second Affiliated Hospital; China	es
uca.version	acceptedVersion	es
item.fulltext	With Fulltext	-
item.languageiso639-1	en	-
item.grantfulltext	open	-
crisitem.author.dept	Instituto de Investigaciones Biomédicas - BIOMED	-
crisitem.author.dept	Laboratorio de Función y Farmacología de Canales Iónicos	-
crisitem.author.dept	Consejo Nacional de Investigaciones Científicas y Técnicas	-
crisitem.author.dept	Facultad de Ciencias Médicas	-
crisitem.author.orcid	0000-0002-0775-8661	-
crisitem.author.parentorg	Facultad de Ciencias Médicas	-
crisitem.author.parentorg	Instituto de Investigaciones Biomédicas - BIOMED	-
crisitem.author.parentorg	Pontificia Universidad Católica Argentina	-
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