Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/9019
DC FieldValueLanguage
dc.contributor.authorPérez Lloret, Santiagoes
dc.contributor.authorBernath, Vivianaes
dc.contributor.authorBarrantes, Francisco Josées
dc.date.accessioned2019-11-12T18:17:36Z-
dc.date.available2019-11-12T18:17:36Z-
dc.date.issued2019-
dc.identifier.citationPérez Lloret, S., Bernath, V., Barrantes, F. J. Genetic factors influencing the development and treatment of cognitive impairment and psychosis in Parkinson’s disease [en línea]. Postprint del capítulo publicado en Gargiulo P., Mesones Arroyo H. (eds). Psychiatry and Neuroscience Update. Springer, Cham, 2019. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9019es
dc.identifier.isbn978-3-319-95359-5-
dc.identifier.isbn978-3-319-95360-1 (online)-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/9019-
dc.description.abstractAbstract: Parkinson’s Disease (PD) is a neurodegenerative disease in which both genetic and environmental factors play significant roles. In addition to increasing the risk of developing PD, gene mutations might also influence the phenotypical characteristics of the disease, including the development of cognitive impairment and psychosis. For instance, mutations of the GBA gene, which encodes the enzyme γ-glucocerebrosidase, have been related to cognitive impairment or dementia and visual hallucinations. Interest in the APOE gene, which encodes the apolipoprotein E, stems from the finding of increased Alzheimer’s Disease risk in carriers of APOE ε4 alleles. In a cohort of 390 PD patients, APOE ε4 allele carriers showed significantly increased cognitive decline during the 2-year follow-up period. Mutations of the LRRK2 gene, which encodes the leucine-rich repeat kinase 2, have been related to a lower risk of cognitive impairment and dementia and lower scores for apathy and hallucinations. PD patients with mutations in the BDNF, COMT, PARP4 and MTCL1 genes showed increased risk cognitive impairment, dementia and visual hallucinations, but these results have not been replicated yet. Hallucinations have also been related to mutations in the cholecystokinin CCK gene. These findings suggest that gene mutations may be important determinants of cognitive impairment and psychosis in PD and highlight promising targets for new therapeutic approaches.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherSpringer, Chames
dc.rightsAcceso abierto. 2 años de embargo*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourcePostprint del capítulo publicado en Gargiulo P., Mesones Arroyo H. (eds). Psychiatry and Neuroscience Update. Springer, Cham, 2019.es
dc.subjectGENETICAes
dc.subjectENFERMEDAD DE PARKINSONes
dc.subjectSINTOMASes
dc.subjectPSIQUIATRIAes
dc.titleGenetic factors influencing the development and treatment of cognitive impairment and psychosis in Parkinson’s diseasees
dc.typeParte de libroes
dc.identifier.doi10.1007/978-3-319-95360-1_29-
uca.disciplinaMEDICINAes
uca.issnrd1es
uca.affiliationFil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Pérez Lloret, Santiago. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas; Argentinaes
uca.affiliationFil: Bernath, Viviana. Genda Laboratorio de Genética y Biología Molecular; Argentinaes
uca.affiliationFil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentinaes
uca.versionacceptedVersiones
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptLaboratorio de Neurobiología Molecular-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Neurobiología Molecular-
crisitem.author.deptFacultad de Ciencias Médicas-
crisitem.author.orcid0000-0001-9069-6512-
crisitem.author.orcid0000-0002-4745-681X-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
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