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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Choi, Jung-Mi | es |
dc.contributor.author | Kim, Sung-Soo | es |
dc.contributor.author | Choi, Chan-Il | es |
dc.contributor.author | Cha, Hye Lim | es |
dc.contributor.author | Oh, Huy-Hyen | es |
dc.contributor.author | Ghil, Sungho | es |
dc.contributor.author | Lee, Young-Don | es |
dc.contributor.author | Birnbaumer, Lutz | es |
dc.contributor.author | Suh-Kim, Haeyoung | es |
dc.date.accessioned | 2019-09-18T16:17:37Z | - |
dc.date.available | 2019-09-18T16:17:37Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Choi J-M, Kim S-S, Choi C-I, et al. Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice [en línea]. Proceedings of the National Academy of Sciences. 2016;113(39):10974-10979. doi:10.1073/pnas.1613026113 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8760 | es |
dc.identifier.issn | 0027-8424 (impreso) | - |
dc.identifier.issn | 1091-6490 (online) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/8760 | - |
dc.description.abstract | Abstract: In mammals, initial detection of olfactory stimuli is mediated by sensory neurons in the main olfactory epithelium (MOE) and the vomeronasal organ (VNO). The heterotrimeric GTP-binding protein Go is widely expressed in the MOE and VNO of mice. Early studies indicated that Go expression in VNO sensory neurons is critical for directing social and sexual behaviors in female mice [Oboti L, et al. (2014) BMC Biol 12:31]. However, the physiological functions of Go in the MOE have remained poorly defined. Here, we examined the role of Go in the MOE using mice lacking the α subunit of Go Development of the olfactory bulb (OB) was perturbed in mutant mice as a result of reduced neurogenesis and increased cell death. The balance between cell types of OB interneurons was altered in mutant mice, with an increase in the number of tyrosine hydroxylase-positive interneurons at the expense of calbindin-positive interneurons. Sexual behavior toward female mice and preference for female urine odors by olfactory sensory neurons in the MOE were abolished in mutant male mice. Our data suggest that Go signaling is essential for the structural and functional integrity of the MOE and for specification of OB interneurons, which in turn are required for the transmission of pheromone signals and the initiation of mating behavior with the opposite sex. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | National Academy of Sciences | es |
dc.rights | Acceso abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Proceedings of the National Academy of Sciences. 2016;113(39):10974-10979 | es |
dc.subject | PROTEINAS | es |
dc.subject | OLFATO | es |
dc.subject | SEXUALIDAD | es |
dc.subject | COMPORTAMIENTO | es |
dc.subject | APOPTOSIS | es |
dc.title | Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1073/pnas.1613026113 | - |
dc.identifier.pmid | 27625425 | - |
uca.disciplina | MEDICINA | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Choi, Jung-Mi. Ajou University School of Medicine. Department of Anatomy; Corea del Sur | es |
uca.affiliation | Fil: Kim, Sung-Soo. Ajou University School of Medicine. Department of Anatomy; Corea del Sur | es |
uca.affiliation | Fil: Choi, Chan-Il. Ajou University School of Medicine. Department of Anatomy; Corea del Sur | es |
uca.affiliation | Fil: Cha, Hye Lim. Ajou University School of Medicine. Department of Anatomy; Corea del Sur | es |
uca.affiliation | Fil: Oh, Huy-Hyen. Ajou University School of Medicine. Department of Anatomy; Corea del Sur | es |
uca.affiliation | Fil: Oh, Huy-Hyen. Ajou University School of Medicine. The Graduate School. Department of Biomedical Sciences; Corea del Sur | es |
uca.affiliation | Fil: Ghil, Sungho. Kyonggi University. Department of Life Science; Corea del Sur | es |
uca.affiliation | Fil: Lee, Young-Don. Ajou University School of Medicine. Department of Anatomy; Corea del Sur | es |
uca.affiliation | Fil: Lee, Young-Don. Ajou University School of Medicine. The Graduate School. Department of Biomedical Sciences; Corea del Sur | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos | es |
uca.affiliation | Fil: Suh-Kim, Haeyoung. Ajou University School of Medicine. Department of Anatomy; Corea del Sur | es |
uca.affiliation | Fil: Suh-Kim, Haeyoung. Ajou University School of Medicine. The Graduate School. Department of Biomedical Sciences; Corea del Sur | es |
uca.version | publishedVersion | es |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Función y Farmacología de Canales Iónicos | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-0775-8661 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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