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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Dube, Prabhatchandra R. | es |
dc.contributor.author | Chikkamenahalli, Lakshmikanth L. | es |
dc.contributor.author | Birnbaumer, Lutz | es |
dc.contributor.author | Vazquez, Guillermo | es |
dc.date.accessioned | 2019-09-10T19:57:37Z | - |
dc.date.available | 2019-09-10T19:57:37Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Dube PR, Chikkamenahalli LL, Birnbaumer L, Vazquez G. Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of TRPC3 [en línea]. Atherosclerosis. 2018;270:199-204. doi:10.1016/j.atherosclerosis.2017.12.025 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8715 | es |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.issn | 1879-1484 (online) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/8715 | - |
dc.description.abstract | Abstract: Background and aims—Recent in vitro studies have showed that in macrophages deletion of the non-selective Ca2+-permeable channel TRPC3 impairs expression of the osteogenic protein BMP-2. The pathophysiological relevance of this effect in atherosclerotic plaque calcification remains to be determined. Methods—We used Ldlr −/− mice with macrophage-specific loss of TRPC3 (MacTrpc3 −/−/Ldlr −/−) to examine the effect of macrophage Trpc3 on plaque calcification and osteogenic features in advanced atherosclerosis. Results—After 25 weeks on high fat diet, aortic root plaques in MacTrpc3 −/−/Ldlr −/− mice showed reduced size, lipid and macrophage content compared to controls. Plaque calcification was decreased in MacTrpc3 −/−/Ldlr −/− mice, and this was accompanied by marked reduction in BMP-2, Runx-2 and phospho-SMAD1/5 contents within macrophage-rich areas. Expression of Bmp-2 and Runx-2 was also reduced in bone marrow-derived macrophages from MacTrpc3 −/−/ Ldlr −/− mice. Conclusions—These findings show that, in advanced atherosclerosis, selective deletion of TRPC3 in macrophages favors plaque regression and impairs the activity of a novel macrophageassociated, BMP-2-dependent mechanism of calcification. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.rights | Acceso Abierto. 1 año de embargo | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Atherosclerosis. 2018;270:199-204. | es |
dc.subject | ARTERIOESCLEROSIS | es |
dc.subject | CALCIFICACION | es |
dc.subject | OSTEOGENESIS | es |
dc.subject | FOSFORILACION | es |
dc.title | Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of TRPC3 | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1016/j.atherosclerosis.2017.12.025 | - |
dc.identifier.pmid | 29290366 | - |
uca.disciplina | MEDICINA | - |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Dube, Prabhatchandra R. University of Toledo. College of Medicine and Life Sciences. Center for Hypertension and Personalized Medicine. Department of Physiology and Pharmacology; Estados Unidos | es |
uca.affiliation | Fil: Chikkamenahalli, Lakshmikanth L. University of Toledo. College of Medicine and Life Sciences. Center for Hypertension and Personalized Medicine. Department of Physiology and Pharmacology; Estados Unidos | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Research Triangle Park. Neurobiology Laboratory; Estados Unidos | es |
uca.affiliation | Fil: Vazquez, Guillermo. University of Toledo. College of Medicine and Life Sciences. Center for Hypertension and Personalized Medicine. Department of Physiology and Pharmacology; Estados Unidos | es |
uca.version | acceptedVersion | es |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Función y Farmacología de Canales Iónicos | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-0775-8661 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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