Por favor, use este identificador para citar o enlazar este ítem: https://repositorio.uca.edu.ar/handle/123456789/8708
Campo DC Valor Lengua/Idioma
dc.contributor.authorLiu, Benjues
dc.contributor.authorHe, Xijues
dc.contributor.authorLi, Shoutianes
dc.contributor.authorXu, Benkees
dc.contributor.authorBirnbaumer, Lutzes
dc.contributor.authorLiao, Yanhonges
dc.date.accessioned2019-09-10T18:51:49Z-
dc.date.available2019-09-10T18:51:49Z-
dc.date.issued2017-
dc.identifier.citationLiu B, He X, Li S, Xu B, Birnbaumer L, Liao Y. Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway [en línea]. American Journal of Translational Research. 2017;9(12):5619-5630. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8708es
dc.identifier.issn1943-8141-
dc.identifier.urihttp://www.ajtr.org/V9_No12.html-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/8708-
dc.description.abstractAbstract: TRPC6 plays a critical role in proteinuric kidney diseases, and TRPC3 is involved in tubulointerstitial damage and renal fibrosis in obstructed kidneys. Podocyte loss is a characteristic event in diabetic nephropathy (DN). The aim of this study was to examine whether deletion of the closely related diacylglycerol (DAG)-responsive TRPCs in mice (TRPC3/6/7-/-) affects diabetes-induced renal dysfunction and podocyte loss. We compared urine volume, kidney hypertrophy, glomerular enlargement, albuminuria and podocyte loss between wild type (WT) and TRPC3/6/7-/- diabetic mice. Finally, we examined whether the TGFβ1 signaling pathway is changed in diabetic WT and TRPC3/6/7-/- mice. TRPC6 protein in the renal cortex was increased in WT diabetic mice. High glucose (HG) treatment increased TRPC6 expression in human podocytes. TRPC3 protein, however, was not altered in either diabetic mice or HG-treated human podocytes. Although diabetic WT and TRPC3/6/7-/- mice had similar levels of hyperglycemia, the TRPC3/6/7-/- diabetic mice showed less polyuria, kidney hypertrophy, glomerular enlargement, albuminuria, and had lost less podocytes compared with WT diabetic mice. In addition, we observed decreased expression of anti-apoptotic Bcl2 and increased expression of pro-apoptotic cleaved caspase 3 in WT diabetic mice, but such changes were not significant in TRPC3/6/7-/- diabetic mice. Western blot and immunohistochemistry revealed that TGFβ1, p-Smad2/3, and fibronectin were upregulated in WT diabetic mice; however, expression of these signaling molecules was not changed in TRPC3/6/7-/- diabetic mice. In conclusion, deletion of DAG-responsive TRPCs attenuates diabetic renal injury via inhibiting the upregulation of TGFβ1 signaling in diabetic kidneys.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publishere-Century Publishinges
dc.rightsAcceso Abierto*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceAmerican Journal of Translational Research. 2017;9(12):5619-5630.es
dc.subjectGLUCOSAes
dc.subjectHIPERGLUCEMIAes
dc.subjectENFERMEDADES RENALESes
dc.subjectRIÑONes
dc.subjectFIBROSISes
dc.subjectDIABETESes
dc.titleDeletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathwayes
dc.typeArtículoes
dc.identifier.pmid29312514-
uca.disciplinaMEDICINA-
uca.issnrd1es
uca.affiliationFil: Liu, Benju. Huazhong University of Science and Technology. Tongji Medical College. Department of Anatomy; Chinaes
uca.affiliationFil: Liu, Benju. Huazhong University of Science and Technology. Tongji Medical College. Institute of Brain Research; Chinaes
uca.affiliationFil: Liu, Benju. Yangtze University. Department of Anatomy; Chinaes
uca.affiliationFil: He, Xiju. Huazhong University of Science and Technology. Tongji Medical College. Department of Anatomy; Chinaes
uca.affiliationFil: He, Xiju. Huazhong University of Science and Technology. Tongji Medical College. Institute of Brain Research; Chinaes
uca.affiliationFil: Li, Shoutian. Huazhong University of Science and Technology. Tongji Medical College. Department of Anatomy; Chinaes
uca.affiliationFil: Li, Shoutian. Huazhong University of Science and Technology. Tongji Medical College. Institute of Brain Research; Chinaes
uca.affiliationFil: Xu, Benke. Yangtze University. Department of Anatomy; Chinaes
uca.affiliationFil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Research Triangle Park. Neurobiology Laboratory; Estados Unidoses
uca.affiliationFil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Científicas; Argentinaes
uca.affiliationFil: Liao, Yanhong. Huazhong University of Science and Technology. Tongji Medical College. Department of Anatomy; Chinaes
uca.affiliationFil: Liao, Yanhong. Huazhong University of Science and Technology. Tongji Medical College. Institute of Brain Research; Chinaes
uca.versionpublishedVersiones
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.languageiso639-1en-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Función y Farmacología de Canales Iónicos-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptFacultad de Ciencias Médicas-
crisitem.author.orcid0000-0002-0775-8661-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
Aparece en las colecciones: Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato
deletion-diacylglycerol-responsive-trpc.pdf1,47 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro sencillo del ítem

Visualizaciones de página(s)

69
comprobado en 27-mar-2024

Descarga(s)

49
comprobado en 27-mar-2024

Google ScholarTM

Consultar



Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons