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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Nobles, Muriel | es |
dc.contributor.author | Montaigne, David | es |
dc.contributor.author | Sebastian, Sonia | es |
dc.contributor.author | Birnbaumer, Lutz | es |
dc.contributor.author | Tinker, Andrew | es |
dc.date.accessioned | 2019-09-10T18:01:18Z | - |
dc.date.available | 2019-09-10T18:01:18Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Nobles M, Montaigne D, Sebastian S, Birnbaumer L, Tinker A. Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria [en línea]. American Journal of Physiology-Cell Physiology. 2018;314(5):C616-C626. doi:10.1152/ajpcell.00271.2016 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8707 | es |
dc.identifier.issn | 0363-6143 | - |
dc.identifier.issn | 1522-1563 (online) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/8707 | - |
dc.description.abstract | Abstract: G protein-gated inwardly rectifying K+ (GIRK) channels are the major inwardly rectifying K+ currents in cardiac atrial myocytes and an important determinant of atrial electrophysiology. Inhibitory G protein α-subunits can both mediate activation via acetylcholine but can also suppress basal currents in the absence of agonist. We studied this phenomenon using whole cell patch clamping in murine atria from mice with global genetic deletion of Gαi2, combined deletion of Gαi1/Gαi3, and littermate controls. We found that mice with deletion of Gαi2 had increased basal and agonist-activated currents, particularly in the right atria while in contrast those with Gαi1/Gαi3 deletion had reduced currents. Mice with global genetic deletion of Gαi2 had decreased action potential duration. Tissue preparations of the left atria studied with a multielectrode array from Gαi2 knockout mice showed a shorter effective refractory period, with no change in conduction velocity, than littermate controls. Transcriptional studies revealed increased expression of GIRK channel subunit genes in Gαi2 knockout mice. Thus different G protein isoforms have differential effects on GIRK channel behavior and paradoxically Gαi2 act to increase basal and agonist-activated GIRK currents. Deletion of Gαi2 is potentially proarrhythmic in the atria. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | American Physiological Society | es |
dc.rights | Acceso Abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | American Journal of Physiology-Cell Physiology. 2018;314(5):C616-C626 | es |
dc.subject | POTASIO | es |
dc.subject | RITMO CARDIACO | es |
dc.subject | ARRITMIA | es |
dc.subject | CORAZON | es |
dc.subject | FIBRILACION AURICULAR | es |
dc.title | Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1152/ajpcell.00271.2016 | - |
dc.identifier.pmid | 29342363 | - |
dc.contributor.orcid | 0000-0002-7654-2565 | - |
uca.disciplina | MEDICINA | - |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Nobles, Muriel. Barts and the London School of Medicine and Dentistry. William Harvey Research Institute. The Heart Centre; Reino Unido | es |
uca.affiliation | Fil: Montaigne, David. Centre Hospitalier Régional Universitaire de Lille; Francia | es |
uca.affiliation | Fil: Montaigne, David. Université Lille 2; Francia | es |
uca.affiliation | Fil: Sebastian, Sonia. Barts and the London School of Medicine and Dentistry. William Harvey Research Institute. The Heart Centre; Reino Unido | es |
uca.affiliation | Fil: Sebastian, Sonia. Institut National de la Santé et de la Recherche Médicale; Francia | es |
uca.affiliation | Fil: Sebastian, Sonia. European Genomic Institute for Diabetes; Francia | es |
uca.affiliation | Fil: Sebastian, Sonia. Institut Pasteur de Lille; Francia | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Research Triangle Park. National Institute of Environmental Health Sciences. Division of Intramural Research; Estados Unidos | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Tinker, Andrew. Barts and the London School of Medicine and Dentistry. William Harvey Research Institute. The Heart Centre; Reino Unido | es |
uca.version | publishedVersion | es |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Función y Farmacología de Canales Iónicos | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-0775-8661 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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