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dc.contributor.authorBaron, Jenses
dc.contributor.authorBilbao, Ainhoaes
dc.contributor.authorHörtnagl, Heidees
dc.contributor.authorBirnbaumer, Lutzes
dc.contributor.authorLeixner, Sarahes
dc.contributor.authorSpanagel, Raineres
dc.contributor.authorAhnert-Hilger, Gudrunes
dc.contributor.authorBrunk, Irenees
dc.date.accessioned2019-09-06T19:07:51Z-
dc.date.available2019-09-06T19:07:51Z-
dc.date.issued2018-
dc.identifier.citationBaron J, Bilbao A, Hörtnagl H, et al. Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system. Journal of Neurochemistry. 2018;146(4):374-389. doi:10.1111/jnc.14460 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8694es
dc.identifier.issn0022-3042-
dc.identifier.issn1471-4159 (online)-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/8694-
dc.description.abstractAbstract: The heterotrimeric G-protein Go with its splice variants, Go1α and Go2α, seems to be involved in the regulation of motor function but isoform-specific effects are still unclear. We found that Go1α-/- knockouts performed worse on the rota-rod than Go2α-/- and wild-type (WT) mice. In Go1+2α-/- mice motor function was partially recovered. Furthermore, Go1+2α-/- mice showed an increased spontaneous motor activity. Compared to wild types or Go2α-/- mice, Go1+2α-/- mice developed increased behavioural sensitization following repetitive cocaine treatment, but failed to develop conditioned place preference. Analysis of dopamine concentration and expression of D1 and D2 receptors unravelled splice-variant-specific imbalances in the striatal dopaminergic system: In Go1α-/- mice dopamine concentration and vesicular monoamine uptake were increased compared to wild types. The expression of the D2 receptor was higher in Go1α-/- compared to wild type littermates, but unchanged in Go2α-/- mice. Deletion of both Go1α and Go2α re-established both dopamine and D2 receptor levels comparable to those in the wild-type. Cocaine treatment had no effect on the ratio of D1 receptor to D2 receptor in Go1+2α-/- mutants, but decreased this ratio in Go2α-/- mice. Finally, we observed that the deletion of Go1α led to a threefold higher striatal expression of Go2α. Taken together our data suggest that a balance in the expression of Go1α and Go2α sustains normal motor function. Deletion of either splice variant results in divergent behavioural and molecular alterations in the striatal dopaminergic system. Deletion of both splice variants partially restores the behavioural and molecular changes.es
dc.formatapplication/pdf-
dc.language.isoenges
dc.publisherWileyes
dc.rightsAcceso Abierto*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceJournal of Neurochemistry. 2018;146(4):374-389es
dc.subjectMOTRICIDADes
dc.subjectCOCAINAes
dc.subjectCOMPORTAMIENTOes
dc.subjectMOTIVACIONes
dc.titleBalance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic systemes
dc.typeArtículoes
dc.identifier.doi10.1111/jnc.14460-
dc.identifier.pmid29747224-
dc.contributor.orcid0000-0002-3301-2628-
uca.disciplinaMEDICINA-
uca.issnrd1es
uca.affiliationFil: Baron, Jens. Charité-Universitätsmedizin. Institute of Integrative Neuroanatomy; Alemaniaes
uca.affiliationFil: Bilbao, Ainhoa. University of Heidelberg. CentralInstitute of Mental Health. Institute of Psychopharmacology. Behavioural Genetics Research Group. Medical Faculty; Alemaniaes
uca.affiliationFil: Hörtnagl, Heide. Innsbruck Medical University. Department of Pharmacology; Austriaes
uca.affiliationFil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentinaes
uca.affiliationFil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Leixner, Sarah. University of Heidelberg. Central Institute of Mental Health. Institute of Psychopharmacology. Behavioural Genetics Research Group. Medical Faculty; Alemaniaes
uca.affiliationFil: Spanagel, Rainer. University ofHeidelberg. Institute of Psychopharmacology. Medical Faculty; Alemaniaes
uca.affiliationFil: Ahnert-Hilger, Gudrun. Charité-Universitätsmedizin. Institute of Integrative Neuroanatomy; Alemaniaes
uca.affiliationFil: Brunk, Irene. Charité-Universitätsmedizin. Institute of Integrative Neuroanatomy; Alemaniaes
uca.versionpublishedVersiones
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.languageiso639-1en-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Función y Farmacología de Canales Iónicos-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptFacultad de Ciencias Médicas-
crisitem.author.orcid0000-0002-0775-8661-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
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