Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/8691
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dc.contributor.authorBorroni, María Virginiaes
dc.contributor.authorVallés, Ana Sofíaes
dc.contributor.authorBarrantes, Francisco Josées
dc.date.accessioned2019-09-06T15:13:32Z-
dc.date.available2019-09-06T15:13:32Z-
dc.date.issued2016-
dc.identifier.citationBorroni MV, Vallés AS, Barrantes FJ. (2016) The lipid habitats of neurotransmitter receptors in brain [en línea]. Biochimica et Biophysica Acta 1858(11). http://dx.doi.org/10.1016/j.bbamem.2016.07.005. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8691es
dc.identifier.issn0005-2736-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/8691-
dc.description.abstractAbstract: Neurotransmitter receptors, the macromolecules specialized in decoding the chemical signals encrypted in the chemical signalingmechanism in the nervous system, occur either at the somatic cell surface of chemically excitable cells or at specialized subcellular structures, the synapses. Synapses have lipid compositions distinct from the rest of the cell membrane, suggesting that neurotransmitter receptors and their scaffolding and adaptor protein partners require specific lipid habitats for optimal operation. In this review we discuss some paradigmatic cases of neurotransmitter receptor-lipid interactions, highlighting the chemical nature of the intervening lipid species and providing examples of the receptor mechanisms affected by interaction with lipids. The focus is on the effects of cholesterol, glycerophospholipids and covalent fatty acid acylation on neurotransmitter receptors.We also briefly discuss the role of lipid phase states involving lateral heterogeneities of the host membrane known to modulate membrane transport, protein sorting and signaling. Modulation of neurotransmitter receptors by lipids occurs at multiple levels, affecting a wide span of activities including their trafficking, sorting, stability, residence lifetime at the cell surface, endocytosis, and recycling, among other important functional properties at the synapse.es
dc.formatapplication/pdf-
dc.language.isoenges
dc.publisherElsevier B.V.es
dc.rightsAcceso abierto*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceBiochimica et Biophysica Acta Vol. 1858, N° 11, 2016es
dc.subjectSINAPSISes
dc.subjectLIPIDOSes
dc.subjectCOLESTEROLes
dc.subjectNEUROTRANSMISORESes
dc.subjectRECEPTORESes
dc.subjectPROTEINASes
dc.subjectMEDICINAes
dc.titleThe lipid habitats of neurotransmitter receptors in braines
dc.typeArtículoes
dc.identifier.doi10.1016/j.bbamem.2016.07.005-
uca.disciplinaMEDICINA-
uca.issnrd1es
uca.affiliationFil: Borroni, María Virginia. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnología en Polímeros y Nanotecnología; Argentinaes
uca.affiliationFil: Vallés, Ana Sofía. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentinaes
uca.affiliationFil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentinaes
uca.versionpublishedVersiones
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Neurobiología Molecular-
crisitem.author.orcid0000-0002-4745-681X-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
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