Por favor, use este identificador para citar o enlazar este ítem:
https://repositorio.uca.edu.ar/handle/123456789/8689
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Antollini, Silvia S. | es |
dc.contributor.author | Barrantes, Francisco José | es |
dc.date.accessioned | 2019-09-05T15:30:13Z | - |
dc.date.available | 2019-09-05T15:30:13Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Antollini SS, Barrantes FJ(2016) Fatty acid regulation of voltage-and ligand-gated ion channel function. Front. Physiol.7:573. doi: 10.3389/fphys.2016.00573. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8689 | es |
dc.identifier.issn | 1664-042X | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/8689 | - |
dc.description.abstract | Abstract: Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to the environment. FFA are continuously being produced and degraded, and a feedback regulatory function has been attributed to their turnover. The massive increase observed under some pathological conditions, especially in brain, has been interpreted as a protective mechanism possibly operative on ion channels, which in some cases is of stimulatory nature and in other cases inhibitory. Here we discuss the correlation between the structure of FFA and their ability to modulate protein function, evaluating the influence of saturation/unsaturation, number of double bonds, and cis vs. trans isomerism. We further focus on the mechanisms of FFA modulation operating on voltage-gated and ligand-gated ion channel function, contrasting the still conflicting evidence on direct vs. indirect mechanisms of action. | es |
dc.format | application/pdf | - |
dc.language.iso | eng | es |
dc.publisher | Frontiers | es |
dc.rights | Acceso abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Frontiers in Physiology Vol. 7, 2016 | es |
dc.subject | MEDICINA | es |
dc.subject | ACIDOS GRASOS LIBRES | es |
dc.subject | MEMBRANAS CELULARES | es |
dc.subject | PROTEINAS | es |
dc.subject | CANALES IONICOS | es |
dc.title | Fatty acid regulation of voltage-and-ligand-gated ion channel function | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.3389/fphys.2016.00573 | - |
uca.disciplina | MEDICINA | - |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Antollini, Silvia S. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina | es |
uca.affiliation | Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina | es |
uca.affiliation | Fil: Barrantes, Franacisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Antollini, Silvia S. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina | es |
uca.version | publishedVersion | es |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Neurobiología Molecular | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-4745-681X | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
fatty-acid-regulation-voltage.pdf | 1,47 MB | Adobe PDF | Visualizar/Abrir |
Visualizaciones de página(s)
169
comprobado en 22-abr-2024
Descarga(s)
154
comprobado en 22-abr-2024
Google ScholarTM
Consultar
Altmetric
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons