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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Tiapko, Oleksandra | es |
dc.contributor.author | Shrestha, Niroj | es |
dc.contributor.author | Lindinger, Sonja | es |
dc.contributor.author | Guedes de la Cruz, Gema | es |
dc.contributor.author | Graziani, Annarita | es |
dc.contributor.author | Klec, Christiane | es |
dc.contributor.author | Butorac, Carmen | es |
dc.contributor.author | Graier, Wolfgang F. | es |
dc.contributor.author | Kubista, Helmut | es |
dc.contributor.author | Freichel, Marc | es |
dc.contributor.author | Birnbaumer, Lutz | es |
dc.contributor.author | Romanin, Christoph | es |
dc.contributor.author | Glasnov, Toma | es |
dc.contributor.author | Groschner, Klaus | es |
dc.date.accessioned | 2019-09-03T21:48:44Z | - |
dc.date.available | 2019-09-03T21:48:44Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Tiapko O, Shrestha N, Lindinger S, et al. Lipid-independent control of endothelial and neuronal TRPC3 channels by light [en línea]. Chemical Science. 2019;10(9):2837-2842. doi:10.1039/C8SC05536J Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8681 | es |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/8681 | - |
dc.description.abstract | Abstract: Lipid-gated TRPC channels are highly expressed in cardiovascular and neuronal tissues. Exerting precise pharmacological control over their activity in native cells is expected to serve as a basis for the development of novel therapies. Here we report on a new photopharmacological tool that enables manipulation of TRPC3 channels by light, in a manner independent of lipid metabolism and with higher temporal precision than lipid photopharmacology. Using the azobenzene photoswitch moiety, we modified GSK1702934A to generate light-controlled TRPC agonists. We obtained one light-sensitive molecule (OptoBI-1) that allows us to exert efficient, light-mediated control over TRPC3 activity and the associated cellular Ca2+ signaling. OptoBI-1 enabled high-precision, temporal control of TRPC3-linked cell functions such as neuronal firing and endothelial Ca2+ transients. With these findings, we introduce a novel photopharmacological strategy to control native TRPC conductances. | es |
dc.format | application/pdf | - |
dc.language.iso | eng | es |
dc.publisher | Royal Society of Chemistry | es |
dc.rights | Acceso Abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Chemical Science. 2019;10(9):2837-2842 | es |
dc.subject | LIPIDOS | es |
dc.subject | FARMACOLOGIA | es |
dc.subject | FISIOLOGIA | es |
dc.subject | CELULAS | es |
dc.subject | LUZ | es |
dc.title | Lipid-independent control of endothelial and neuronal TRPC3 channels by light | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1039/c8sc05536j | - |
dc.identifier.pmid | 30997005 | - |
uca.disciplina | MEDICINA | - |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Tiapko, Oleksandra. Medical University of Graz. Gottfried Schatz Research Center Biophysics; Austria | es |
uca.affiliation | Fil: Shrestha, Niroj. Medical University of Graz. Gottfried Schatz Research Center Biophysics; Austria | es |
uca.affiliation | Fil: Lindinger, Sonja. University of Linz. Institute of Biophysics; Austria | es |
uca.affiliation | Fil: Guedes de la Cruz, Gema. University of Graz. Institute of Chemistry; Austria | es |
uca.affiliation | Fil: Graziani, Annarita. Medical University of Graz. Gottfried Schatz Research Center Biophysics; Austria | es |
uca.affiliation | Fil: Klec, Christiane. Medical University of Graz. Gottfried Schatz Research Center Molecular Biology and Biochemistry; Austria | es |
uca.affiliation | Fil: Butorac, Carmen. Medical University of Graz. Gottfried Schatz Research Center Biophysics; Austria | es |
uca.affiliation | Fil: Graier, Wolfgang F. Medical University of Graz. Gottfried Schatz Research Center Molecular Biology and Biochemistry; Austria | es |
uca.affiliation | Fil: Kubista, Helmut. Medical University of Vienna. Institute of Pharmacology; Austria | es |
uca.affiliation | Fil: Freichel, Marc. Universität Heidelberg. Pharmakologisches Institut; Alemania | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Research Triangle Park. National Institute of Environmental Health Sciences. Neurobiology Laboratory; Estados Unidos | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Romanin, Christoph. University of Linz. Institute of Biophysics; Austria | es |
uca.affiliation | Fil: Glasnov, Toma. University of Graz. Institute of Chemistry; Austria | es |
uca.affiliation | Fil: Groschner, Klaus. Medical University of Graz. Gottfried Schatz Research Center Biophysics; Austria | es |
uca.version | publishedVersion | es |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Función y Farmacología de Canales Iónicos | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-0775-8661 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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