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https://repositorio.uca.edu.ar/handle/123456789/8567
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Sodero, Alejandro Omar | es |
dc.contributor.author | Rodriguez-Silva, Mónica | es |
dc.contributor.author | Salio, Chiara | es |
dc.contributor.author | Sassoè-Pognetto, Marco | es |
dc.contributor.author | Chambers, Jeremy W. | es |
dc.date.accessioned | 2019-08-14T20:00:44Z | - |
dc.date.available | 2019-08-14T20:00:44Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Sodero, AO, Rodriguez-Silva, M, Sassoè-Pognetto, M, Chambers, JW. Sab is differentially expressed in the brain and affects neuronal activity [en línea] Brain Research. 2017;1670:76-85. doi:10.1016/j.brainres.2017.06.005 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8567 | es |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/8567 | - |
dc.description.abstract | Abstract: Sab (SH3 binding protein 5 or SH3BP5) is a mitochondrial scaffold protein involved in signaling associated with mitochondrial dysfunction and apoptosis; furthermore, Sab is a crucial signaling platform for neurodegenerative disease. To determine how this signaling nexus could have a significant effect on disease, we examined the regional abundance of Sab in the brain and sub-neuronal distribution, and we monitored the effect of Sab-mediated signaling on neuronal activity. We found that Sab is widely expressed in the adult mouse brain with increased abundance in hippocampus, ventral midbrain, and cerebellum. Sab was found in purified synaptosomes and in cultures of hippocampal neurons and astrocytes. Confocal and electron microscopy of mouse hippocampal sections confirmed the mitochondrial localization of Sab in the soma, dendrites, and axons. Given the localization and sub-neuronal distribution of Sab, we postulated that Sab-mediated signaling could affect neuronal function, so we measured the impact of inhibiting Sab-mediated events on the spontaneous activity in cultured hippocampal neurons. Treatment with a Sab-inhibitory peptide (Tat-SabKIM1), but not a scrambled control peptide, decreased the firing frequency and spike amplitudes. Our results demonstrate that brain-specific Sab-mediated signaling plays a role in neuronal activity through the manipulation of mitochondrial physiology by interacting kinases. | es |
dc.format | application/pdf | - |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.rights | Acceso Abierto. 12 meses de embargo | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Brain Research. 2017;1670:76-85 | es |
dc.subject | PROTEINAS | es |
dc.subject | QUINASA | es |
dc.subject | ACTIVIDAD NEURONAL | es |
dc.subject | CEREBRO | es |
dc.title | Sab is differentially expressed in the brain and affects neuronal activity | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1016/j.brainres.2017.06.005 | - |
dc.identifier.pmid | 28606781 | - |
uca.disciplina | CIENCIAS MEDICAS | - |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Sodero, Alejandro Omar. Florida International University. Herbert Wertheim College of Medicine. Department of Cellular Biology and Pharmacology; Estados Unidos | es |
uca.affiliation | Fil: Sodero, Alejandro Omar. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Sodero, Alejandro Omar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Rodriguez-Silva, Mónica. Florida International University. Herbert Wertheim College of Medicine. Department of Cellular Biology and Pharmacology; Estados Unidos | es |
uca.affiliation | Fil: Salio, Chiara. University of Turin. Department of Veterinary Sciences; Italia | es |
uca.affiliation | Fil: Sassoè-Pognetto, Marco. University of Turin. Department of Neuroscience; Italia | es |
uca.affiliation | Fil: Chambers, Jeremy W. Florida International University. Herbert Wertheim College of Medicine. Department of Cellular Biology and Pharmacology; Estados Unidos | es |
uca.affiliation | Fil: Chambers, Jeremy W. Florida International University. Herbert Wertheim College of Medicine. Department of Cellular Biology and Pharmacology; Estados Unidos | es |
uca.affiliation | Fil: Chambers, Jeremy W. Florida International University. Biomolecular Sciences Institute; Estados Unidos | es |
uca.version | acceptedVersion | es |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Neurobiología Molecular | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0001-5159-218X | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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