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dc.contributor.authorBrown, Gregory M.es
dc.contributor.authorKarthikeyan, Ramanujames
dc.contributor.authorPandi Perumal, Seithikurippu R.es
dc.contributor.authorCardinali, Daniel Pedroes
dc.date.accessioned2024-06-27T11:28:24Z-
dc.date.available2024-06-27T11:28:24Z-
dc.date.issued2021-
dc.identifier.citationBrown, G. M. et al. Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin [en línea]. Medical Hypotheses. 2021, 149 . doi: 10.1016/j.mehy.2021.110544. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/18344es
dc.identifier.issn0306-9877-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/18344-
dc.description.abstractAbstract: Patients with Autism Spectrum Disorder (ASD) may be particularly prone to develop COVID-19. An unusual extended course of COVID-19 disease illness has been reported in one ASD patient and a group of patients have COVID-19 disease in a neurodevelopmental facility. It has been widely reported that many of those with ASD have substantial sleep disorders with low levels of melatonin and various genetic alterations related to melatonin production have been found. Several lines of evidence point to a substantial role of melatonin in the body’s innate defense system including acting as a scavenger, an antioxidant and modulating the immune system. We therefore hypothesize that melatonin deficiency may predispose those ASD patients who have low melatonin output to COVID-19 disease. Potential implications for treatment are discussed.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rightsAcceso abierto*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceMedical Hypotheses. 2021, 149es
dc.subjectTRASTORNO DEL ESPECTRO AUTISTAes
dc.subjectCOVID-19es
dc.subjectSARS-CoV-2es
dc.subjectMELATONINAes
dc.titleAutism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonines
dc.typeArtículoes
dc.identifier.doi10.1016/j.mehy.2021.110544-
uca.disciplinaMEDICINAes
uca.issnrd1es
uca.affiliationFil: Brown, Gregory M. University of Toronto. Department of Psychiatry. Centre for Addiction and Mental Health; Canadáes
uca.affiliationFil: Karthikeyan, Ramanujam. Investigador independiente; Indiaes
uca.affiliationFil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc; Canadáes
uca.affiliationFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultaf de Ciencias Médicas; Argentinaes
uca.versionpublishedVersiones
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextWith Fulltext-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptFacultad de Ciencias Médicas-
crisitem.author.orcid0000-0002-0813-9088-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
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