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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Hertz, Laura | es |
dc.contributor.author | Flormann, Daniel | es |
dc.contributor.author | Birnbaumer, Lutz | es |
dc.contributor.author | Wagner, Christian | es |
dc.contributor.author | Laschke, Matthias W. | es |
dc.contributor.author | Kaestner, Lars | es |
dc.date.accessioned | 2023-10-31T10:38:08Z | - |
dc.date.available | 2023-10-31T10:38:08Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Hertz, L. et al. Evidence of in vivo exogen protein uptake by red blood cells: a putative therapeutic concept [en línea]. Blood Advances. 2023, 7(6). doi: 10.1182/bloodadvances.2022008404. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/17371 | es |
dc.identifier.issn | 2473-9537 (online) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/17371 | - |
dc.description.abstract | Abstract: For some molecular players in red blood cells (RBCs), the functional indications and molecular evidence are discrepant. One such protein is transient receptor potential channel of canonical subfamily, member 6 (TRPC6). Transcriptome analysis of reticulocytes revealed the presence of TRPC6 in mouse RBCs and its absence in human RBCs. We transfused TRPC6 knockout RBCs into wild-type mice and performed functional tests. We observed the “rescue” of TRPC6 within 10 days; however, the “rescue” was slower in splenectomized mice. The latter finding led us to mimic the mechanical challenge with the cantilever of an atomic force microscope and simultaneously carry out imaging by confocal (3D) microscopy. We observed the strong interaction of RBCs with the opposed surface at around 200 pN and the formation of tethers. The results of both the transfusion experiments and the atomic force spectroscopy suggest mechanically stimulated protein transfer to RBCs as a protein source in the absence of the translational machinery. This protein transfer mechanism has the potential to be utilized in therapeutic contexts, especially for hereditary diseases involving RBCs, such as hereditary xerocytosis or Gárdos channelopathy. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | American Society of Hematology | es |
dc.rights | Acceso abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Blood Advances. Vol.7, No.6, 2023 | es |
dc.subject | GLOBULOS ROJOS | es |
dc.subject | HIERRO | es |
dc.subject | ERITROPOYESIS | es |
dc.title | Evidence of in vivo exogen protein uptake by red blood cells: a putative therapeutic concept | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1182/bloodadvances.2022008404 | - |
dc.identifier.pmid | 36490356 | - |
uca.disciplina | MEDICINA | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Hertz, Laura. Saarland University. Medical Faculty. Theoretical Medicine and Biosciences; Alemania | es |
uca.affiliation | Fil: Flormann, Daniel. Saarland University. Experimental Physics. Dynamics of Fluids; Alemania | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Instituto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Laboratory of Signal Transduction; Estados Unidos | es |
uca.affiliation | Fil: Wagner, Christian. Saarland University. Experimental Physics. Dynamics of Fluids; Alemania | es |
uca.affiliation | Fil: Wagner, Christian. University of Luxembourg. Physics and Materials Science Research Unit; Luxemburgo | es |
uca.affiliation | Fil: Laschke, Matthias W. Saarland University. Institute for Clinical and Experimental Surgery. Medical Faculty; Alemania | es |
uca.affiliation | Fil: Kaestner, Lars. Saarland University. Medical Faculty. Theoretical Medicine and Biosciences; Alemania | es |
uca.affiliation | Fil: Kaestner, Lars. Saarland University. Experimental Physics. Dynamics of Fluids; Alemania | es |
uca.version | publishedVersion | es |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Función y Farmacología de Canales Iónicos | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-0775-8661 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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