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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Alami, Abdallah | es |
dc.contributor.author | Krewski, Daniel | es |
dc.contributor.author | Farhat, Nawal | es |
dc.contributor.author | Mattison, Donald | es |
dc.contributor.author | Wilson, Kumanan | es |
dc.contributor.author | Gravel, Christopher A. | es |
dc.contributor.author | Farrell, Patrick J. | es |
dc.contributor.author | Crispo, James A. G. | es |
dc.contributor.author | Pérez Lloret, Santiago | es |
dc.contributor.author | Villeneuve, Paul J. | es |
dc.contributor.author | Haddad, Nisrine | es |
dc.date.accessioned | 2023-10-24T13:54:59Z | - |
dc.date.available | 2023-10-24T13:54:59Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Alami, A. et al. Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis [en línea]. BMJ Open. 2023, 13(6):e065687. doi: 10.1136/bmjopen-2022-065687. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/17346 | es |
dc.identifier.issn | 2044-6055 | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/17346 | - |
dc.description.abstract | Abstract: Objective To summarise the available evidence on the risk of myocarditis and/or pericarditis following mRNA COVID-19 vaccination, compared with the risk among unvaccinated individuals in the absence of COVID-19 infection. Design Systematic review and meta-analysis. Data sources Electronic databases (Medline, Embase, Web of Science and WHO Global Literature on Coronavirus Disease), preprint repositories (medRxiv and bioRxiv), reference lists and grey literature were searched from 1 December 2020 until 31 October 2022. Study selection Epidemiological studies of individuals of any age who received at least one dose of an mRNA COVID-19 vaccine, reported a risk of myo/pericarditis and compared the risk of myo/pericarditis to individuals who did not receive any dose of an mRNA COVID-19 vaccine. Data extraction and synthesis Two reviewers independently conducted screening and data extraction. The rate of myo/pericarditis among vaccinated and unvaccinated groups was recorded, and the rate ratios were calculated. Additionally, the total number of individuals, case ascertainment criteria, percentage of males and history of SARS-CoV-2 infection were extracted for each study. Meta-analysis was done using a randomeffects model. Results Seven studies met the inclusion criteria, of which six were included in the quantitative synthesis. Our metaanalysis indicates that within 30-day follow-up period, vaccinated individuals were twice as likely to develop myo/pericarditis in the absence of SARS-CoV-2 infection compared to unvaccinated individuals, with a rate ratio of 2.05 (95% CI 1.49–2.82). Conclusion Although the absolute number of observed myo/pericarditis cases remains quite low, a higher risk was detected in those who received mRNA COVID-19 vaccinations compared with unvaccinated individuals in the absence of SARS-CoV-2 infection. Given the effectiveness of mRNA COVID-19 vaccines in preventing severe illnesses, hospitalisations and deaths, future research should focus on accurately determining the rates of myo/pericarditis linked to mRNA COVID-19 vaccines, understanding the biological mechanisms behind these rare cardiac events and identifying those most at risk. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | BMJ Publishing Group | es |
dc.rights | Acceso abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | BMJ Open Vol.13, No.6: e065687, 2023 | es |
dc.subject | COVID-19 | es |
dc.subject | EPIDEMIOLOGIA | es |
dc.subject | SALUD PUBLICA. | es |
dc.subject | MIOCARDITIS | es |
dc.subject | PERICARDITIS | es |
dc.title | Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1136/bmjopen-2022-065687 | - |
uca.disciplina | MEDICINA | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Alami, Abdallah. Carleton University. School of Mathematics and Statistics. Faculty of Science; Canadá | es |
uca.affiliation | Fil: Krewski, Daniel. University of Ottawa. School of Epidemiology and Public Health. Faculty of Medicine; Canadá | es |
uca.affiliation | Fil: Krewski, Daniel. Risk Sciences International; Canadá | es |
uca.affiliation | Fil: Farhat, Nawal. Carleton University. School of Mathematics and Statistics. Faculty of Science; Canadá | es |
uca.affiliation | Fil: Mattison, Donald. University of Ottawa. School of Epidemiology and Public Health. Faculty of Medicine; Canadá | es |
uca.affiliation | Fil: Mattison, Donald. Risk Sciences International; Canadá | es |
uca.affiliation | Fil: Mattison, Donald. University of South Carolina. Arnold School of Public Health; Estados Unidos | es |
uca.affiliation | Fil: Wilson, Kumanan. University of Ottawa. Bruyère Research Institute; Canadá | es |
uca.affiliation | Fil: Wilson, Kumanan. Ottawa Hospital Research Institute; Canadá | es |
uca.affiliation | Fil: Gravel, Christopher A. University of Ottawa. School of Epidemiology and Public Health. Faculty of Medicine; Canadá | es |
uca.affiliation | Fil: Gravel, Christopher A. Risk Sciences International; Canadá | es |
uca.affiliation | Fil: Farrell, Patrick J. Carleton University. School of Mathematics and Statistics. Faculty of Science; Canadá | es |
uca.affiliation | Fil: Crispo, James A. G. The University of British Columbia. Faculty of Pharmaceutical Sciences; Canadá | es |
uca.affiliation | Fil: Crispo, James A. G. University of Northern Ontario School of Medicine. Division of Human Sciences; Canadá | es |
uca.affiliation | Fil: Haddad, Nisrine. University of Ottawa. School of Epidemiology and Public Health. Faculty of Medicine; Canadá | es |
uca.affiliation | Fil: Haddad, Nisrine. Risk Sciences International; Canadá | es |
uca.affiliation | Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Observatorio de Salud Pública; Argentina | es |
uca.affiliation | Fil: Pérez Lloret, Santiago. Universidad de Buenos Aires. Facultad de Medicina, Departamento de Fisiología; Argentina | es |
uca.affiliation | Fil: Villeneuve, Paul J. Carleton University. Faculty of Science. Department of Neurosciences; Canadá | es |
uca.version | publishedVersion | es |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Laboratorio de Neurobiología Molecular | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.orcid | 0000-0001-9069-6512 | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
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