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https://repositorio.uca.edu.ar/handle/123456789/1657
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Cano Barquilla, Pilar | es |
dc.contributor.author | Pagano, Eleonora Samanta | es |
dc.contributor.author | Jiménez Ortega, Vanesa | es |
dc.contributor.author | Fernández Mateos, María P. | es |
dc.contributor.author | Esquifino, Ana I. | es |
dc.contributor.author | Cardinali, Daniel Pedro | es |
dc.date.accessioned | 2019-05-02T14:01:18Z | - |
dc.date.available | 2019-05-02T14:01:18Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Cano Barquilla, P., et al. Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats [en línea]. Preprint del documento publicado en Journal of Pineal Research 2014, 57. doi:10.1111/jpi.12168. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1657 | es |
dc.identifier.issn | 0742-3098 (impreso) | - |
dc.identifier.issn | 1600-079X (online) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/1657 | - |
dc.description.abstract | Abstract: The objective of the present study was to evaluate the efficacy of melatonin to affect mild inflammation in the metabolic syndrome (MS) induced by a high-fat diet in rats. Adult Wistar male rats were divided into four groups (n= 16/group): (i) control diet (3% fat); (ii) high-fat (35%) diet; (iii) high-fat diet + melatonin; (iv) melatonin. Rats had free access to high-fat or control chow and one of the following drinking solutions for 10 weeks: (a) tap water; (b) 25 μg/mL of melatonin. Plasma interleukin (IL)-1β, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon (IFN)-γ and C-reactive protein (CRP) were measured at two time intervals, i.e. the middle of daylight period and the middle of the scotophase. In addition, a number of somatic and metabolic components employed clinically to monitor the MS were measured. Melatonin decreased the augmented circulating levels of IL-1β, IL-6, TNF-α, IFN-γ and CRP seen in obese rats and restored the depressed levels of IL-4 and IL-10. Rats fed with the high-fat diet showed significantly higher body weights and augmented systolic blood pressure from the 3rd and 4th week onwards, respectively, melatonin effectively preventing these changes. In high-fat fed rats circulating low-density lipoprotein-cholesterol, total cholesterol and triglyceride concentration augmented significantly, melatonin being effective to counteract these changes. Melatonin-treated rats showed a decreased insulin resistance, the highest values of plasma high-density lipoprotein-cholesterol and the lowest values of plasma uric acid. The results indicate that melatonin is able to normalize the altered biochemical proinflammatory profile seen in rats fed with a high-fat diet | es |
dc.format | application/pdf | es |
dc.language | eng | es |
dc.language.iso | eng | es |
dc.rights | Acceso Abierto | es |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | es |
dc.source | Preprint del documento publicado en Journal of pineal research, Nº 57, 2014 | es |
dc.subject | DISLIPIDEMIA | es |
dc.subject | TOLERANCIA A LA GLUCOSA | es |
dc.subject | DIETA | es |
dc.subject | HIPERTENSION | es |
dc.subject | INFLAMACION | es |
dc.subject | ACIDO URICO | es |
dc.title | Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1111/jpi.12168 | - |
uca.path | Facultad de Ciencias Médicas|Departamento de Docencia e Investigación | es |
uca.disciplina | MEDICINA | es |
uca.filename | /home/data-uca-generic/folder_generic/IIBiomedicas/melatonin-normalizes-clinical-biochemical/metadata.xml | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Cano Barquilla, Pilar. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; España | es |
uca.affiliation | Fil: Pagano, Eleonora S. Pontifica Universidad Católica Argentina. Faculta de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina | es |
uca.affiliation | Fil: Jiménez Ortega, Vanesa. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; España | es |
uca.affiliation | Fil: Fernández Mateos, Pilar. Universidad Complutense. Facultad de Medicina. Departamento de Biología Celular; España | es |
uca.affiliation | Fil: Esquifino, Ana I. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; España | es |
uca.affiliation | Fil: Cardinali, Daniel P. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina | es |
uca.version | submittedVersion | es |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Psiconeuroendocrinoinmunología | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-0813-9088 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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