Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/1643
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dc.contributor.authorJiménez Ortega, Vanesaes
dc.contributor.authorCardinali, Daniel Pedroes
dc.contributor.authorFernández Mateos, María P.es
dc.contributor.authorRíos Lugo, María J.es
dc.contributor.authorScacchi, Pabloes
dc.contributor.authorEsquifino, Ana I.es
dc.date.accessioned2019-05-02T14:01:14Z-
dc.date.available2019-05-02T14:01:14Z-
dc.date.issued2010-
dc.identifier.citationJiménez-Ortega, V., et al. Effect of cadmium on 24-hour pattern in expression of redox enzime and clock genes in rat medial basal hypothalamus [en línea]. Preprint del artículo publicado en Biometals. 2010, 23 (2). doi:10.1007/s10534-010-9292-6. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1643es
dc.identifier.issn1572-8773 (online)-
dc.identifier.issn0966-0844 (impreso)-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/1643-
dc.description.abstractAbstract: The effect of cadmium (Cd) in the brain has been attributed to an increase in reactive oxygen species in cells, particularly when high amounts of the metal are given. In this study we examined the effect of a low dose of Cd (7.5 μg/day) on 24-h changes in expression of redox pathway enzyme and circadian genes in rat medial basal hypothalamus (MBH). Rats receiving CdCl2 (5 ppm in drinking water) or tap water for one month were killed at 6 different time intervals throughout a 24 h cycle. MBH mRNA levels were measured by real-time PCR analysis. In CdCl2 treated rats a disruption of 24-h pattern of hypothalamic gene expression of nitric oxide synthase (NOS)-1 and -2, heme oxygenase (HO)-1 and -2, Mn- superoxide dismutase (SOD), catalase, glutathione peroxidase and glutathione reductase was detectable. Mean levels of MBH mRNA for HO-2, Mn-SOD and catalase augmented after Cd intake, whereas those of NOS-2 decreased. After CdCl2 intake rats the 24-h pattern of clock gene expression in MBH seen in controls was significantly suppressed (Bmal1) or changed in phase (Per1, Per2, Cry2) while in the case of Clock significant 24-h variations were induced. The results are compatible with the view that a low amount of Cd given in tap water brought about significant changes in circadian expression of redox enzyme and clock genes in rat MBH.es
dc.formatapplication/pdfes
dc.languageenges
dc.language.isoenges
dc.publisherSpringeres
dc.rightsAcceso Abiertoes
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/es
dc.sourceBiometals. 2010, 23 (2)es
dc.subjectRITMO CIRCADIANOes
dc.subjectOXIDO NITRICO SINTASAes
dc.subjectHEMO-OXIGENASAes
dc.subjectSUPEROXIDO DISMUTASAes
dc.subjectCATALASAes
dc.subjectGLUTATION PEROXIDASAes
dc.subjectGLUTATION REDUCTASAes
dc.subjectCADMIOes
dc.subjectHIPOTALAMO MEDIOes
dc.subjectEXPRESION GENICAes
dc.titleEffect of cadmium on 24-hour pattern in expression of redox enzime and clock genes in rat medial basal hypothalamuses
dc.typeArtículoes
dc.identifier.doi10.1007/s10534-010-9292-6-
uca.pathFacultad de Ciencias Médicas|Departamento de Docencia e Investigaciónes
uca.disciplinaMEDICINAes
uca.filename/home/data-uca-generic/folder_generic/IIBiomedicas/effect-cadmium-pattern-redox-enzyme/metadata.xmles
uca.issnrd1es
uca.affiliationFil: Jiménez Ortega, Vanesa. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; Españaes
uca.affiliationFil: Cardinali, Daniel P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Departamento de Docencia e Investigación; Argentinaes
uca.affiliationFil: Fernández Mateos, María P. Universidad Complutense. Facultad de Medicina. Departamento de Biología Celular; Españaes
uca.affiliationFil: Ríos Lugo, María J. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; Españaes
uca.affiliationFil: Scacchi Bernasconi, Pablo A. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentinaes
uca.affiliationFil: Esquifino, Ana I. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; Españaes
uca.versionsubmittedVersiones
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.orcid0000-0002-0813-9088-
crisitem.author.parentorgFacultad de Ciencias Médicas-
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